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Literature summary extracted from

  • Sanden, C.; Enquist, J.; Bengtson, S.H.; Herwald, H.; Leeb-Lundberg, F.L.
    Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation (2008), J. Pharmacol. Exp. Ther., 326, 24-32.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.15 expression of N-terminally HA- or FLAG-tagged enzyme in HEK-293 cells, subcellular localization in the transformed cells, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.15 cell surface secretion to the medium Homo sapiens 9986
-
3.4.24.15 cytosol
-
 Homo sapiens 5829
-
3.4.24.15 extracellular
-
 Homo sapiens
-
-
3.4.24.15 intracellular intracellular EP24.15 is present throughout the cell, both cytosolic and particulate, with less nuclear localization and no co-localization with either the endoplasmatic reticulum marker calnexin or Golgi marker GM130, overview Homo sapiens 5622
-
3.4.24.15 particle-bound
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.15 additional information EP24.15 is a metalloendopeptidase Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.15 78000
-
 x * 78000 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.15 amyloid precursor protein + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.15 angiotensin-I + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.15 angiotensin-II + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.15 bradykinin + H2O Homo sapiens participation of EP24.15 in the metabolism of bradykinin, bradykinin is internalized via the kinin B2 receptor, EP24.15 attenuates maximal kinin2 receptor responsiveness without influencing the potency of bradykinin to stimulate phosphoinositide hydrolysis and intracellular Ca2+ mobilization, overview ?
-
 ?
3.4.24.15 dynorphin A1-8 + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.15 gonadotropin releasing hormone + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.15 brain
-
 Homo sapiens
-
3.4.24.15 gonad
-
 Homo sapiens
-
3.4.24.15 HEK-293 cell
-
 Homo sapiens
-
3.4.24.15 additional information ubiquitous expression Homo sapiens
-
3.4.24.15 pituitary gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.15 amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.15 angiotensin-I + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.15 angiotensin-II + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.15 bradykinin + H2O degradation Homo sapiens ?
-
 ?
3.4.24.15 bradykinin + H2O participation of EP24.15 in the metabolism of bradykinin, bradykinin is internalized via the kinin B2 receptor, EP24.15 attenuates maximal kinin2 receptor responsiveness without influencing the potency of bradykinin to stimulate phosphoinositide hydrolysis and intracellular Ca2+ mobilization, overview Homo sapiens ?
-
 ?
3.4.24.15 dynorphin A1-8 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.15 gonadotropin releasing hormone + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.15 ? x * 78000 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.15 EP24.15
-
 Homo sapiens