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Literature summary extracted from

  • Padilla, B.E.; Cottrell, G.S.; Roosterman, D.; Pikios, S.; Muller, L.; Steinhoff, M.; Bunnett, N.W.
    Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins (2007), J. Cell Biol., 179, 981-997.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.71 overexpression of GFP-tagged isozymes in HEK cell endosomes, subcellular localization, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.71 additional information ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.71 endosome early Homo sapiens 5768
-
3.4.24.71 membrane endosomal Homo sapiens 16020
-
3.4.24.71 plasma membrane
-
 Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.71 additional information ECE-1 is a metallo-endopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.71 angiotensin-I + H2O Homo sapiens degradation, no activity with angiotensin-II ?
-
 ?
3.4.24.71 bradykinin + H2O Homo sapiens degradation ?
-
 ?
3.4.24.71 calcitonin gene-related peptide + H2O Homo sapiens degradation, co-internalization with ECE-1 into early endosomes, calcitonin gene-related peptide degradation promotes CLR/RAMP1 recycling and beta-arrestin2 redistribution into the cytosol, ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, mechanism, overview ?
-
 ?
3.4.24.71 additional information Homo sapiens isoforms of endothelin-converting enzyme-1, ECE-1a-d, are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors, ECE-1 does not regulate either the resensitization of receptors for peptides that are not ECE-1 substrates, e.g. angiotensin II, or the recycling of the bradykinin B2 receptor, which transiently interacts with beta-arrestins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.71 Homo sapiens
-
 4 isoforms of endothelin-converting enzyme-1, ECE-1a-d
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.71 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.71 angiotensin-I + H2O degradation, no activity with angiotensin-II Homo sapiens ?
-
 ?
3.4.24.71 bradykinin + H2O degradation Homo sapiens ?
-
 ?
3.4.24.71 calcitonin gene-related peptide + H2O degradation Homo sapiens ?
-
 ?
3.4.24.71 calcitonin gene-related peptide + H2O degradation, co-internalization with ECE-1 into early endosomes, calcitonin gene-related peptide degradation promotes CLR/RAMP1 recycling and beta-arrestin2 redistribution into the cytosol, ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, mechanism, overview Homo sapiens ?
-
 ?
3.4.24.71 additional information isoforms of endothelin-converting enzyme-1, ECE-1a-d, are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors, ECE-1 does not regulate either the resensitization of receptors for peptides that are not ECE-1 substrates, e.g. angiotensin II, or the recycling of the bradykinin B2 receptor, which transiently interacts with beta-arrestins Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.71 ECE-1
-
 Homo sapiens
3.4.24.71 endothelin-converting enzyme-1
-
 Homo sapiens