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Literature summary extracted from

  • Serrano, S.M.; Kim, J.; Wang, D.; Dragulev, B.; Shannon, J.D.; Mann, H.H.; Veit, G.; Wagener, R.; Koch, M.; Fox, J.W.
    The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting (2006), J. Biol. Chem., 281, 39746-39756.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.73 additional information
-
 additional information quantitative analysis of the interaction of enzyme with Von Willebrand factor, VWF, A1 domains, overview Bothrops jararaca

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.73 extracellular
-
 Bothrops jararaca
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.73 collagen XII + H2O Bothrops jararaca
-
 ?
-
 ?
3.4.24.73 collagen XIV + H2O Bothrops jararaca
-
 ?
-
 ?
3.4.24.73 matrilin 1 + H2O Bothrops jararaca
-
 ?
-
 ?
3.4.24.73 matrilin 3 + H2O Bothrops jararaca
-
 ?
-
 ?
3.4.24.73 matrilin 4 + H2O Bothrops jararaca
-
 ?
-
 ?
3.4.24.73 additional information Bothrops jararaca the enzyme is a hemorrhagic P-III snake venom metalloproteinase ?
-
 ?
3.4.24.73 von Willebrand factor + H2O Bothrops jararaca Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at sites adjacent to the A1 domain ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.73 Bothrops jararaca
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.73 venom
-
 Bothrops jararaca
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.73 collagen XII + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.73 collagen XII + H2O bovine substrate, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview Bothrops jararaca ?
-
 ?
3.4.24.73 collagen XIV + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.73 collagen XIV + H2O bovine substrate, a fibril-associated collagen with interrupted triple helices, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview Bothrops jararaca ?
-
 ?
3.4.24.73 matrilin 1 + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.73 matrilin 1 + H2O bovine substrate, the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains Bothrops jararaca ?
-
 ?
3.4.24.73 matrilin 3 + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.73 matrilin 3 + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains, cleavage pattern, overview Bothrops jararaca ?
-
 ?
3.4.24.73 matrilin 4 + H2O
-
 Bothrops jararaca ?
-
 ?
3.4.24.73 matrilin 4 + H2O the substrate contains Von Willebrand factor A1 domains, which interacts with the enzyme's cysteine-rich domain promoting site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains Bothrops jararaca ?
-
 ?
3.4.24.73 additional information the enzyme is a hemorrhagic P-III snake venom metalloproteinase Bothrops jararaca ?
-
 ?
3.4.24.73 additional information the enzyme's disintegrin-like/cysteine-rich domains target it to to key extracellular matrix proteins or cell surface proteins, overview Bothrops jararaca ?
-
 ?
3.4.24.73 von Willebrand factor + H2O Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at sites adjacent to the A1 domain Bothrops jararaca ?
-
 ?
3.4.24.73 von Willebrand factor + H2O Von Willebrand factor A1 domain interacts with the enzyme's cysteine-rich domain, which promotes site-specific proteolysis, jararhagin cleaves the substrate at or near the A1 domains Bothrops jararaca ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.73 More snake venom metalloproteinases are members of the reprolysin family of metalloproteinases Bothrops jararaca