EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.35 | platelet-activating factor | i.e. 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, induces MMP-9 enzyme expression, and increases enzyme content and activity | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.35 | additional information | both NF-jB and AP-1 inhibitors inhibit MMP-9 expression | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.35 | Ca2+ | dependent on | Mus musculus | |
3.4.24.35 | Zn2+ | dependent on | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.35 | Gelatin + H2O | Mus musculus | - |
? | - |
? | |
3.4.24.35 | additional information | Mus musculus | MMP-9 inhibitor completely inhibits PAF-induced B16F10 metastasis | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.35 | Mus musculus | - |
female C57BL/6 mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.35 | B16-F10 cell | murine melanoma cell line, with platelet-activating factor-induced experimental pulmonary metastasis, which is inhibited by both NF-jB and c-jun inhibitors and completelyby MMP-9 inhibitor | Mus musculus | - |
3.4.24.35 | blood vessel | in the walls | Mus musculus | - |
3.4.24.35 | bronchial epithelial cell | - |
Mus musculus | - |
3.4.24.35 | lung | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.35 | Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
3.4.24.35 | Gelatin + H2O | gelatin zymography | Mus musculus | ? | - |
? | |
3.4.24.35 | additional information | MMP-9 inhibitor completely inhibits PAF-induced B16F10 metastasis | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.35 | matrix metalloproteinase-9 | - |
Mus musculus |
3.4.24.35 | MMP-9 | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.24.35 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.35 | 7.4 | - |
assay at | Mus musculus |