EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.37 | gene ela2 | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.37 | A127P | a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme | Homo sapiens |
3.4.21.37 | A57T | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability | Homo sapiens |
3.4.21.37 | C151S | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | C151Y | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | C71R | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | C71S | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | G210V | a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme | Homo sapiens |
3.4.21.37 | G214R | a naturally occuring disease causing mutation, the mutation affects enzyme stability | Homo sapiens |
3.4.21.37 | G85E | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | H53L | a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme | Homo sapiens |
3.4.21.37 | I60T | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | L121P | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability | Homo sapiens |
3.4.21.37 | L152P | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability | Homo sapiens |
3.4.21.37 | L47P | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability | Homo sapiens |
3.4.21.37 | L84P | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | additional information | mutations in the HNE gene ela2 cause cyclic and congenital neutropenia | Homo sapiens |
3.4.21.37 | P205R | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | P42L | a naturally occuring disease causing mutation, the mutation increase beta-aggregation propensity in the enzyme | Homo sapiens |
3.4.21.37 | R220Q | a naturally occuring disease causing mutation, the mutation causes loss of stability | Homo sapiens |
3.4.21.37 | R81P | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability | Homo sapiens |
3.4.21.37 | S46F | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability, and the mutation increase beta-aggregation propensity in the enzyme | Homo sapiens |
3.4.21.37 | V101M | a naturally occuring disease causing mutation, the mutation affects enzyme stability | Homo sapiens |
3.4.21.37 | V82M | a naturally occuring disease causing mutation, the mutation causes loss of stability and affects enzyme stability | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.37 | azurophil granule | enzyme synthesis | Homo sapiens | 42582 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.37 | 30000 | - |
x * 30000 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.37 | Antithrombin III + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.21.37 | Collagen + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.21.37 | Elastin + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.21.37 | Fibrin + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.21.37 | Fibrinogen + H2O | Homo sapiens | degradation | ? | - |
? | |
3.4.21.37 | additional information | Homo sapiens | the enzyme digests microbes after phagocytosis in polymorphonuclear neutrophil primary granules, which fuse with neutrophil phagolysosomes, and also acts extracellularly at sites of inflammation, overview, mutations in the human neutrophil elastase gene cause cyclic and congenital neutropenia leading to an immunodeficiency characterized by decreased or oscillating levels of neutrophils in the blood | ? | - |
? | |
3.4.21.37 | Proteoglycan + H2O | Homo sapiens | degradation | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.37 | Homo sapiens | P08246 | gene ela2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.37 | neutrophil | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.37 | Antithrombin III + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.21.37 | Collagen + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.21.37 | Elastin + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.21.37 | Fibrin + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.21.37 | Fibrinogen + H2O | degradation | Homo sapiens | ? | - |
? | |
3.4.21.37 | additional information | the enzyme digests microbes after phagocytosis in polymorphonuclear neutrophil primary granules, which fuse with neutrophil phagolysosomes, and also acts extracellularly at sites of inflammation, overview, mutations in the human neutrophil elastase gene cause cyclic and congenital neutropenia leading to an immunodeficiency characterized by decreased or oscillating levels of neutrophils in the blood | Homo sapiens | ? | - |
? | |
3.4.21.37 | additional information | structure-function relationships, overview | Homo sapiens | ? | - |
? | |
3.4.21.37 | Proteoglycan + H2O | degradation | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.37 | ? | x * 30000 | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.37 | ELA2 | - |
Homo sapiens |
3.4.21.37 | HNE | - |
Homo sapiens |
3.4.21.37 | leukocyte elastase | - |
Homo sapiens |
3.4.21.37 | neutrophil elastase | - |
Homo sapiens |