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Literature summary extracted from
- Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs (2007), Growth Horm. IGF Res., 17, 10-18.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.79 | additional information | the enzyme expression in fibroblasts is stimulated by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the stimulation is inhibited by resveratrol | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.79 | diagnostics | PAPP-A is a circulating biomarker for acute coronary syndrome | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.79 | DNA and amino acid sequence determination and anaylsis, sequence comparisons | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.79 | additional information | construction of enzyme knockout mice, dwarf phenotype with decreased body size and IGF-II deficiency, overview | Mus musculus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.79 | extracellular | - |
Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Drosophila melanogaster |  |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Mus musculus | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Homo sapiens | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Rattus norvegicus | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Xenopus laevis | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Caenorhabditis elegans | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Danio rerio | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Takifugu rubripes | |
| 3.4.24.79 | Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Tetraodon nigroviridis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.79 | IGF-binding protein-4 + H2O | Homo sapiens | i.e. IGFBP-4 | ? | - |
? | |
| 3.4.24.79 | additional information | Homo sapiens | regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.79 | Caenorhabditis elegans | - |
- |
- |
| 3.4.24.79 | Danio rerio | - |
- |
- |
| 3.4.24.79 | Drosophila melanogaster | - |
- |
- |
| 3.4.24.79 | Homo sapiens | - |
- |
- |
| 3.4.24.79 | Mus musculus | - |
- |
- |
| 3.4.24.79 | Rattus norvegicus | - |
- |
- |
| 3.4.24.79 | Takifugu rubripes | - |
- |
- |
| 3.4.24.79 | Tetraodon nigroviridis | - |
- |
- |
| 3.4.24.79 | Xenopus laevis | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.79 | proteolytic modification | the enzyme performs autocatalytic cleavage | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.79 | artery | - |
Homo sapiens | - |
| 3.4.24.79 | fibroblast | - |
Homo sapiens | - |
| 3.4.24.79 | heart | coronary artery smooth muscle cells | Homo sapiens | - |
| 3.4.24.79 | smooth muscle cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.79 | IGF-binding protein-4 + H2O | i.e. IGFBP-4 | Homo sapiens | ? | - |
? | |
| 3.4.24.79 | additional information | regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview | Homo sapiens | ? | - |
? | |
| 3.4.24.79 | additional information | domain structure and function, overview, the enzyme performs autocatalytic cleavage | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.79 | More | primary sequence, structure motifs, and domain structure and function, the first 350 amino acid residues comprise the proteolytic domain, overview | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.79 | PAPP-A | - |
Drosophila melanogaster |
| 3.4.24.79 | PAPP-A | - |
Mus musculus |
| 3.4.24.79 | PAPP-A | - |
Homo sapiens |
| 3.4.24.79 | PAPP-A | - |
Rattus norvegicus |
| 3.4.24.79 | PAPP-A | - |
Xenopus laevis |
| 3.4.24.79 | PAPP-A | - |
Caenorhabditis elegans |
| 3.4.24.79 | PAPP-A | - |
Danio rerio |
| 3.4.24.79 | PAPP-A | - |
Takifugu rubripes |
| 3.4.24.79 | PAPP-A | - |
Tetraodon nigroviridis |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Drosophila melanogaster |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Mus musculus |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Homo sapiens |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Rattus norvegicus |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Xenopus laevis |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Caenorhabditis elegans |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Danio rerio |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Takifugu rubripes |
| 3.4.24.79 | pregnancy-associated plasma protein-A | - |
Tetraodon nigroviridis |
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Release 2023.1 (January 2023)
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