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Literature summary extracted from

  • Kim, M.M.; Kim, S.K.
    Chitooligosaccharides inhibit activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts (2006), FEBS Lett., 580, 2661-2666.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.24 chitooligosaccharides inhibit MMP-2 enzyme expression, decrease of the gene expression and transcriptional activity of MMP-2, and catalytic activity in primary dermal fibroblasts, chitooligosaccharides of 3-5 kDa are most effective Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.24 Gelatin + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.24 additional information Homo sapiens chitooligosaccharides may play an important role in the prevention and treatment of several MMP-2 mediated health problems such as metastasis and wrinkle formation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.24 fibroblast primary dermal Homo sapiens
-
3.4.24.24 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.24 Gelatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.24 Gelatin + H2O gelatin zymography Homo sapiens ?
-
 ?
3.4.24.24 additional information chitooligosaccharides may play an important role in the prevention and treatment of several MMP-2 mediated health problems such as metastasis and wrinkle formation, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.24 matrix metalloproteinase-2
-
 Homo sapiens
3.4.24.24 MMP-2
-
 Homo sapiens