Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Goeminne, A.; McNaughton, M.; Bal, G.; Surpateanu, G.; Van Der Veken, P.; De Prol, S.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
    Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors (2008), Eur. J. Med. Chem., 43, 315-326.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.1 (1S)-1,4-dideoxy-1-(2-guanidinoethyl)-1,4-imino-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-(3-guanidinopropyl)-1,4-imino-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(4-amidinobenzyl)-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1,4-dideoxy-1,4-imino-N-(4-guanidinobenzyl)-D-ribitol
-
 Trypanosoma vivax
3.2.2.1 1-guanidino-2,5-anhydro-1-deoxy-D-allitol
-
 Trypanosoma vivax
3.2.2.1 1-guanidino-3,6-anhydro-1,2-dideoxy-D-allo-heptitol
-
 Trypanosoma vivax
3.2.2.1 N-benzyl-1,4-dideoxy-1,4-imino-D-ribitol
-
 Trypanosoma vivax

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.1 Trypanosoma vivax
-
 isoform IAG-NH
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.1 4-nitrophenyl beta-D-ribofuranoside + H2O
-
 Trypanosoma vivax 4-nitrophenol + D-ribose
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.2.1 0.0061
-
 1,4-dideoxy-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.0067
-
 1,4-dideoxy-1,4-imino-N-(4-amidinobenzyl)-D-ribitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.007
-
 1,4-dideoxy-1,4-imino-N-(4-guanidinobenzyl)-D-ribitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.018
-
 (1S )-1,4-dideoxy-1-(2-guanidinoethyl)-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.04
-
 1,4-dideoxy-(3-guanidinopropyl)-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.059
-
 N-benzyl-1,4-dideoxy-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.309
-
 1-guanidino-3,6-anhydro-1,2-dideoxy-D-allo-heptitol pH 7.0, 35°C Trypanosoma vivax
3.2.2.1 0.545
-
 1-guanidino-2,5-anhydro-1-deoxy-D-allitol pH 7.0, 35°C Trypanosoma vivax