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Literature summary extracted from

  • Olivo, R.A.; Nascimento, N.G.; Teixeira, C.F.; Silveira, P.F.
    Methotrexate and cyclosporine treatments modify the activities of dipeptidyl peptidase IV and prolyl oligopeptidase in murine macrophages (2008), Clin. Dev. Immunol., 2008, 794050.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.26 methotrexate
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 benzyloxycarbonyl-Pro-prolinal
-
 Mus musculus
3.4.21.26 cyclosporine A the activating effect of methotrexate dominates the inhibitory effect of cyclosporine A Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.26 soluble
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.26 bradykinin + H2O Mus musculus
-
 ?
-
 ?
3.4.21.26 Substance P + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Mus musculus
-
 male Swiss strain mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
-
 Mus musculus benzyloxycarbonyl-Gly-Pro + 2-naphthylamine
-
 ?
3.4.21.26 bradykinin + H2O
-
 Mus musculus ?
-
 ?
3.4.21.26 Gly-Pro-4-methoxy-beta-naphthylamide + H2O
-
 Mus musculus Gly-Pro + 4-methoxy-beta-naphthylamine
-
 ?
3.4.21.26 Substance P + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 POP
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.26 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.26 7.4
-
 assay at Mus musculus