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Literature summary extracted from

  • Sun, Z.; Sood, S.; Li, N.; Ramji, D.; Yang, P.; Newman, R.A.; Yang, C.S.; Chen, X.
    Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors (2006), Carcinogenesis, 27, 1902-1908.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.6 medicine the 5-Lox/LTA4H pathway is involved in 7,12-dimethylbenz[alpha]anthracene induced oral carcinogenesis and may be targeted for chemoprevention of oral cancer Cricetulus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 bestatin
-
 Cricetulus sp.
3.3.2.6 SA6541
-
 Cricetulus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O Cricetulus sp.
-
 (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Cricetulus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 cheek pouch
-
 Cricetulus sp.
-
3.3.2.6 squamous epithelium squamous epithelium of hamster oral mucosa Cricetulus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
-
 Cricetulus sp. (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene-A4 hydrolase
-
 Cricetulus sp.
3.3.2.6 LTA4H
-
 Cricetulus sp.