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Literature summary extracted from

  • Khrenov, A.V.; Ananyeva, N.M.; Saenko, E.L.
    Role of the B domain in proteolytic inactivation of activated coagulation factor VIII by activated protein C and activated factor X (2006), Blood Coagul. Fibrinolysis, 17, 379-388.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.6 additional information
-
 additional information kinetics of FVIIIa inactivation Homo sapiens
3.4.21.69 additional information
-
 additional information kinetics Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.69 Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.6 activated factor VIII + H2O Homo sapiens proteolytic inactivation factor VIII
-
 ?
3.4.21.6 factor VIII + H2O Homo sapiens proteolytic activation by removal of the B domain activated factor VIII + B domain
-
 ?
3.4.21.69 active factor Va + H2O Homo sapiens proteolytic inactivation of the cofactor in the prothrombinase complex inactive factor V + ?
-
 ?
3.4.21.69 active factor VIII + H2O Homo sapiens activated protein C and activated factor X play a role in proteolytic inactivation of activated coagulation factor VIII involving the B domain, the inactivated substrate factor VIII is less efficient on blood clotting, overview inactive factor VIII + domain B
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Homo sapiens
-
-
-
3.4.21.69 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.69 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 activated factor VIII + H2O proteolytic inactivation Homo sapiens factor VIII
-
 ?
3.4.21.6 activated factor VIII + H2O inactivation by cleavage at Arg336 and Lys36 of domain A1, low activity Homo sapiens factor VIII
-
 ?
3.4.21.6 factor VIII + H2O proteolytic activation by removal of the B domain Homo sapiens activated factor VIII + B domain
-
 ?
3.4.21.6 factor VIII + H2O activation by cleavage at Arg1689 and Arg1721 of domain A3 Homo sapiens activated factor VIII + B domain
-
 ?
3.4.21.69 active factor Va + H2O proteolytic inactivation Homo sapiens inactive factor V + ?
-
 ?
3.4.21.69 active factor Va + H2O proteolytic inactivation of the cofactor in the prothrombinase complex Homo sapiens inactive factor V + ?
-
 ?
3.4.21.69 active factor VIII + H2O activated protein C and activated factor X play a role in proteolytic inactivation of activated coagulation factor VIII involving the B domain, the inactivated substrate factor VIII is less efficient on blood clotting, overview Homo sapiens inactive factor VIII + domain B
-
 ?
3.4.21.69 active factor VIIIa + H2O proteolytic inactivation, cleavage at Arg336 and Arg572 in domains A1 and A2, respectively Homo sapiens inactive factor VIII + domain B
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 activated factor X
-
 Homo sapiens
3.4.21.6 FXa
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.69 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.69 7.2
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.69 protein S complexed witht the activated protein C, increases the activity 6-10fold Homo sapiens