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Literature summary extracted from

  • Schuette, A.; Lottaz, D.; Sterchi, E.E.; Stoecker, W.; Becker-Pauly, C.
    Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio (2007), Biol. Chem., 388, 523-531.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.63 4 genes encoding alpha and beta subunits of the enzyme are located on chromosome 20, DNA and amino acid sequence determination and anaylsis, phylogenetic tree, sequence comparisons, overview Danio rerio

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.63 Zn2+ a zinc metalloprotease with the zinc-binding motif HExxHxxGxxHE(or M) Danio rerio

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.63 73000
-
x * 73000, SDS-PAGE Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.63 Danio rerio
-
-
-
3.4.24.63 Danio rerio F1QRQ5 meprin alpha2 subunit
-
3.4.24.63 Danio rerio Q5RHM1 meprin alpha1 subunit
-
3.4.24.63 Danio rerio Q5RKM1 meprin alpha1 subunit
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.63 glycoprotein
-
Danio rerio

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.63 brain
-
Danio rerio
-
3.4.24.63 epidermis
-
Danio rerio
-
3.4.24.63 epithelium
-
Danio rerio
-
3.4.24.63 intestine
-
Danio rerio
-
3.4.24.63 kidney
-
Danio rerio
-
3.4.24.63 leukocyte intestinal Danio rerio
-
3.4.24.63 liver
-
Danio rerio
-
3.4.24.63 lung
-
Danio rerio
-
3.4.24.63 pancreas
-
Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.63 additional information residues of the alpha1 subunit involved in the active site are Asp61 and Arg150, catalytic domain structure, overview Danio rerio ?
-
?
3.4.24.63 additional information residues of the alpha2 subunit involved in the active site are Glu80 and Lys122, catalytic domain structure, overview Danio rerio ?
-
?
3.4.24.63 additional information the residue of the beta subunit involved in the active site is Lys123, catalytic domain structure, overview Danio rerio ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.24.63 ? x * 73000, SDS-PAGE Danio rerio
3.4.24.63 More all three meprin subunits identified in zebrafish contain the typical astacin domain, the Met-turn SxMHY, and the four cysteine residues that form two disulfide bonds Danio rerio

Synonyms

EC Number Synonyms Comment Organism
3.4.24.63 More the enzyme is a member of the astacin family of metalloproteases Danio rerio