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Literature summary extracted from

  • Barsun, M.; Jajcanin, N.; Vukeli?, B.; Spoljari?, J.; Abrami?, M.
    Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins (2007), Biol. Chem., 388, 343-348.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.4 Gly-Gly-Phe-Leu enkephalin fragment Homo sapiens
3.4.14.4 Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg Leu-valorphin-Arg Homo sapiens
3.4.14.4 Tyr(SO3H)-Gly-Gly-Phe-Leu
-
 Homo sapiens
3.4.14.4 Tyr-Ala-Gly-Phe-Leu Ala2-Leu-enkephalin Homo sapiens
3.4.14.4 Tyr-D-Ala-Gly-Phe-Leu D-Ala2-Leu-enkephalin Homo sapiens
3.4.14.4 Tyr-Gly-Gly-Phe enkephalin fragment Homo sapiens
3.4.14.4 Tyr-Gly-Gly-Phe-Leu Leu-enkephalin Homo sapiens
3.4.14.4 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile dynorphin A 1-8 Homo sapiens
3.4.14.4 Tyr-Pro-Phe-Phe-NH2 endomorphin-2 Homo sapiens
3.4.14.4 Tyr-Pro-Phe-Val-Glu-Pro-Ile human beta-casomorphin Homo sapiens
3.4.14.4 Tyr-Pro-Trp-Phe-NH2 endomorphin-1 Homo sapiens
3.4.14.4 Val-Val-Tyr-Pro-Trp-Thr-Gln valorphin Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.4 0.0081
-
 Tyr-Pro-Trp-Phe-NH2 endomorphin-1 Homo sapiens
3.4.14.4 0.0222
-
 Arg-Arg-2-naphthylamide
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.14.4 Zn2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.14.4 82000
-
 determined by PAGE, native and denaturing conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.14.4 the protein is purified from human erythrocytes Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.4 cerebrospinal fluid
-
 Homo sapiens
-
3.4.14.4 erythrocyte
-
 Homo sapiens
-
3.4.14.4 spinal cord superficial laminae of the spinal cord dorsal horn Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.14.4 87.5
-
 in the presence of 10 microM CoCl2 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.4 Arg-Arg-2-naphthylamide + H2O substrate used in the activity assay Homo sapiens Arg-Arg + 2-naphthylamine
-
 ?
3.4.14.4 Tyr-Pro-Trp-Phe-NH2 + H2O endomorphin-1 Homo sapiens Tyr-Pro + Trp-Phe-NH2
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.14.4 monomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.14.4 dipeptidyl arylamidase III
-
 Homo sapiens
3.4.14.4 dipeptidyl peptidase III
-
 Homo sapiens
3.4.14.4 DPP III
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.14.4 37
-
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.14.4 2 8 Arg-Arg-2-naphthylamide
-
 Homo sapiens
3.4.14.4 5
-
 Tyr-Pro-Trp-Phe-NH2 endomorphin-1 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.4 7.4
-
 physiological condition, determination of Ki values and kinetic parameters of the hydrolysis of endomorphin-1 Homo sapiens
3.4.14.4 8.6
-
 assay condition with the synthetic substrate Arg-Arg-2-naphthylamide, determination of specific activity Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.14.4 0.000049
-
 Val-Val-Tyr-Pro-Trp-Thr-Gln
-
 Homo sapiens
3.4.14.4 0.000375
-
 Tyr-Ala-Gly-Phe-Leu
-
 Homo sapiens
3.4.14.4 0.00056
-
 Tyr-Pro-Phe-Val-Glu-Pro-Ile
-
 Homo sapiens
3.4.14.4 0.00249
-
 Tyr-Pro-Phe-Phe-NH2
-
 Homo sapiens
3.4.14.4 0.00341
-
 Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg
-
 Homo sapiens
3.4.14.4 0.00365
-
 Tyr-Gly-Gly-Phe-Leu
-
 Homo sapiens
3.4.14.4 0.004
-
 Tyr-Gly-Gly-Phe
-
 Homo sapiens
3.4.14.4 0.005
-
 Tyr-Pro-Trp-Phe-NH2
-
 Homo sapiens
3.4.14.4 0.0235
-
 Gly-Gly-Phe-Leu
-
 Homo sapiens
3.4.14.4 0.027
-
 Tyr-D-Ala-Gly-Phe-Leu
-
 Homo sapiens
3.4.14.4 0.0434
-
 Tyr(SO3H)-Gly-Gly-Phe-Leu
-
 Homo sapiens
3.4.14.4 0.0699
-
 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.14.4 Homo sapiens
-
-
 4.5