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Literature summary extracted from

  • Skidgel, R.A.; Stanisavljevic, S.; Erdoes, E.G.
    Kinin- and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells (2006), Biol. Chem., 387, 159-165.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.12 IFN-gamma CPM activity can be upregulated approximately two-fold in HLMVECs by IL-1beta plus IFN-gamma treatment Homo sapiens
3.4.17.12 IL-1beta CPM activity can be upregulated approximately two-fold in HLMVECs by IL-1beta plus IFN-gamma treatment, IL-1beta alone can upregulate CPM expression Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.12 DL-2-mercaptomethyl-3-guanidino-ethylthiopropanoic acid
-
 Bos taurus
3.4.17.12 DL-2-mercaptomethyl-3-guanidino-ethylthiopropanoic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.12 plasma membrane
-
 Homo sapiens 5886
-
3.4.17.12 plasma membrane
-
 Bos taurus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.12 Bos taurus
-
-
-
3.4.17.12 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.12 glycoprotein glycosylphosphatidylinositol-anchored protein Homo sapiens
3.4.17.12 glycoprotein glycosylphosphatidylinositol-anchored protein Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.12 endothelial cell
-
 Homo sapiens
-
3.4.17.12 endothelial cell
-
 Bos taurus
-
3.4.17.12 human lung microvascular endothelial cell HLMVEC Homo sapiens
-
3.4.17.12 lung
-
 Homo sapiens
-
3.4.17.12 lung
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.12 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O bradykinin Homo sapiens Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
-
 ?
3.4.17.12 Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O bradykinin Bos taurus Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
-
 ?
3.4.17.12 Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O kallidin Homo sapiens Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
-
 ?
3.4.17.12 Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O kallidin Bos taurus Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.12 carboxypeptidase M
-
 Homo sapiens
3.4.17.12 carboxypeptidase M
-
 Bos taurus