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Literature summary extracted from

  • Gozzo, A.J.; Nunes, V.A.; Cruz-Silva, I.; Carmona, A.K.; Nader, H.B.; Faljoni-Alario, A.; Sampaio, M.U.; Araujo, M.S.
    Heparin modulation of human plasma kallikrein on different substrates and inhibitors (2006), Biol. Chem., 387, 1129-1138.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.34 alpha1-antiprotease
-
 Homo sapiens
3.4.21.34 antithrombin inhibition by antithrombin is 3.4fold improved by heparin, forming a ternary complex with antithrombin Homo sapiens
3.4.21.34 C1-inhibitor inhibition by C1-inhibitor is 1.4fold improved by heparin Homo sapiens
3.4.21.34 heparin improves inhibition by other enzyme inhibitor 1.4-3.4fold, the enzyme binds to a heparin-matrix, but its secondary structure is not modified by heparin, circular dichroism, overview Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.34 0.0006
-
 plasminogen pH 8.0, 37°C Homo sapiens
3.4.21.34 0.00075
-
 high-molecular-weight kininogen pH 8.0, 37°C Homo sapiens
3.4.21.34 0.0024
-
 Factor XII pH 8.0, 37°C Homo sapiens
3.4.21.34 0.0049
-
 2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine pH 8.0, 37°C Homo sapiens
3.4.21.34 0.269
-
 H-D-Pro-Phe-Arg-4-nitroanilide pH 8.0, 37°C Homo sapiens
3.4.21.34 0.736
-
 acetyl-Phe-Arg-4-nitroanilide pH 8.0, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.34 88000
-
 x * 88000 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 additional information Homo sapiens the enzyme involved in intrinsic blood clotting, the kallikrein-kinin system and fibrinolysis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.34 glycoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
 Homo sapiens 2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg + Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
 ?
3.4.21.34 acetyl-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.34 factor XII + H2O proteolytic activation Homo sapiens activated factor XII + ?
-
 ?
3.4.21.34 H-D-Pro-Phe-Arg-4-nitroanilide + H2O i.e. S2302, a chromogenic substrate Homo sapiens ?
-
 ?
3.4.21.34 high-molecular-weight kininogen + H2O
-
 Homo sapiens high-molecular-weight kinin + bradykinin bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg ?
3.4.21.34 additional information the enzyme involved in intrinsic blood clotting, the kallikrein-kinin system and fibrinolysis Homo sapiens ?
-
 ?
3.4.21.34 plasminogen + H2O proteolytic activation Homo sapiens plasmin + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.34 ? x * 88000 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.34 37
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.34 0.00034
-
 plasminogen pH 8.0, 37°C Homo sapiens
3.4.21.34 0.001
-
 Factor XII pH 8.0, 37°C Homo sapiens
3.4.21.34 0.0306
-
 high-molecular-weight kininogen pH 8.0, 37°C Homo sapiens
3.4.21.34 0.1
-
 2-aminobenzoic acid-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine pH 8.0, 37°C Homo sapiens
3.4.21.34 37.7
-
 acetyl-Phe-Arg-4-nitroanilide pH 8.0, 37°C Homo sapiens
3.4.21.34 37.7
-
 H-D-Pro-Phe-Arg-4-nitroanilide pH 8.0, 37°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.34 8
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.34 additional information
-
 additional information inhibition kinetics and secondorder rate constants Homo sapiens