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Literature summary extracted from
- Beta-secretase (BACE1) inhibitors from Perilla frutescens var. acuta (2008), Arch. Pharm. Res., 31, 183-187.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.23.46 | medicine | screening of natural products for anti-dementia agents | Perilla frutescens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.46 | luteolin | isolated from methanolic extracts of Perilla frutescens | Perilla frutescens |  |
| 3.4.23.46 | rosmarinic acid | isolated from methanolic extracts of Perilla frutescens | Perilla frutescens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.46 | Perilla frutescens | - |
var. acuta | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.23.46 | additional information | methanolic extracts of Perilla frutescens | Perilla frutescens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.46 | additional information | - |
beta-secretase (BACE1) inhibitors isolated from the methanolic extract of Perilla frutescens characterized, specificity against beta-secretase BACE1 higher than for other enzymes such as alpha-secretase (TACE), acetylcholine esterase (AchE), chymotrypsin, and elastase | Perilla frutescens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.46 | additional information | inhibitors of beta-secretase BACE1 identified and tested | Perilla frutescens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.46 | BACE1 | - |
Perilla frutescens |
| 3.4.23.46 | beta-secretase | - |
Perilla frutescens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.23.46 | 0.039 | - |
rosmarinic acid | - |
Perilla frutescens | |
| 3.4.23.46 | 0.062 | - |
luteolin | - |
Perilla frutescens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.23.46 | 0.0005 | - |
non-competitive inhibition | Perilla frutescens | luteolin | |
| 3.4.23.46 | 0.0021 | - |
non-competitive inhibition | Perilla frutescens | rosmarinic acid | |
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