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Literature summary extracted from

  • Fawcett, J.; Permana, P.A.; Levy, J.L.; Duckworth, W.C.
    Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing (2007), Arch. Biochem. Biophys., 468, 128-133.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.56 additional information siRNA-mediated gene silencing of IDE in Hep-G2 cells leading to 50% reduction of IDE mRNA and protein, short-lived protein degradation is unchanged in the cells with reduced IDE expression, while long-lived and very-long-lived protein degradation is reduced, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 insulin + H2O Homo sapiens IDE is involved in the cellular insulin metabolism, insulin inhibits protein degradation via an interaction with IDE, regulation of protein degradation by insulin-degrading enzyme, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 Hep-G2 cell
-
 Homo sapiens
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3.4.24.56 liver
-
 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 insulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O IDE is involved in the cellular insulin metabolism, insulin inhibits protein degradation via an interaction with IDE, regulation of protein degradation by insulin-degrading enzyme, overview Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Homo sapiens
3.4.24.56 Insulin-degrading enzyme
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 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.56 7.4
-
 assay at Homo sapiens