Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Deshmukh, H.S.; Shaver, C.; Case, L.M.; Dietsch, M.; Wesselkamper, S.C.; Hardie, W.D.; Korfhagen, T.R.; Corradi, M.; Nadel, J.A.; Borchers, M.T.; Leikauf, G.D.
    Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production (2008), Am. J. Respir. Cell Mol. Biol., 38, 446-454.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.35 acrolein activates MMP-9 via EGFR/MAPK signaling and stimulation of pro-MMP-9 cleavage Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.35 Ca2+
-
 Mus musculus
3.4.24.35 Zn2+
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.35 86000
-
 x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE Mus musculus
3.4.24.35 103000
-
 x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.35 Gelatin + H2O Mus musculus
-
 ?
-
 ?
3.4.24.35 additional information Mus musculus acrolein subtypes A and C from cigarette smoke induces persistent mucin production via activation of matrix metalloproteinase 9 through induction of pro-MMP-9 cleavage and activation and EGFR/MAPK signaling also leading to MMP-9 activation, regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.35 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.35 proteolytic modification acrolein stimulates pro-MMP-9 cleavage and activation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.35 lung
-
 Mus musculus
-
3.4.24.35 respiratory tract
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.35 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.35 Gelatin + H2O gelatin zymography Mus musculus ?
-
 ?
3.4.24.35 additional information acrolein subtypes A and C from cigarette smoke induces persistent mucin production via activation of matrix metalloproteinase 9 through induction of pro-MMP-9 cleavage and activation and EGFR/MAPK signaling also leading to MMP-9 activation, regulation, overview Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.35 ? x * 103000, about, pro-MMP9, SDS-PAGE, x * 86000, about, activated MMP-9, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.35 Matrix metalloproteinase 9
-
 Mus musculus
3.4.24.35 MMP-9
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.35 37
-
 assay at Mus musculus