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Literature summary extracted from

  • Stepniak, D.; Spaenij-Dekking, L.; Mitea, C.; Moester, M.; de Ru, A.; Baak-Pablo, R.; van Veelen, P.; Edens, L.; Koning, F.
    Highly efficient gluten degradation with a newly identified: implications for celiac disease (2006), Am. J. Physiol. Gastrointest. Liver Physiol., 291, G621-G629.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.26 nutrition oral supplementation of celiac patients with postproline cutting enzymes could be a valuable method to eradicate the proline-rich T cell stimulatory epitopes from gluten proteins, the Aspergillus niger enzyme is a good candidate because it is highly resistant to acidic conditions and degradation by pepsin, found in the stomach, in contrast to other POPs Aspergillus niger

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 additional information the enzyme is completely resistant to digestion with pepsin Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.26 gluten + H2O Aspergillus niger activity in the human host gastrointestinal tract, overview ?
-
 ?
3.4.21.26 gluten peptides + H2O Aspergillus niger activity in the human host gastrointestinal tract, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Aspergillus niger
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 Ala-Ala-Pro-4-nitroanilide + H2O
-
 Aspergillus niger Ala-Ala-Pro + 4-nitroaniline
-
 ?
3.4.21.26 gluten + H2O
-
 Aspergillus niger ?
-
 ?
3.4.21.26 gluten + H2O activity in the human host gastrointestinal tract, overview Aspergillus niger ?
-
 ?
3.4.21.26 gluten peptides + H2O
-
 Aspergillus niger ?
-
 ?
3.4.21.26 gluten peptides + H2O activity in the human host gastrointestinal tract, overview Aspergillus niger ?
-
 ?
3.4.21.26 N-carbobenzyloxy-glycyl-proline-4-methyloumarin-7-amide + H2O
-
 Aspergillus niger N-carbobenzyloxy-glycyl-proline + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 prolyl endoprotease
-
 Aspergillus niger

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.26 37
-
 assay at Aspergillus niger

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.26 4 5
-
 Aspergillus niger

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.26 2 12
-
 Aspergillus niger

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.21.26 2
-
 the enzyme remains stable at pH 2.0 Aspergillus niger