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Literature summary extracted from

  • Zdrazilova, P.; Stepankova, S.; Komersova, A.; Vranova, M.; Komers, K.; Cegan, A.
    Kinetics of 13 new cholinesterase inhibitors (2006), Z. Naturforsch. C, 61, 611-617.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 2-chlorophenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 2-chlorophenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 3-chlorophenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 3-chlorophenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates inhibit quickly by carbamoylation Bos taurus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates inhibit quickly by carbamoylation Electrophorus electricus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
 Bos taurus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
 Electrophorus electricus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
 Bos taurus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
 Electrophorus electricus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
 Bos taurus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
 Electrophorus electricus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
 Bos taurus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
 Electrophorus electricus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
 Bos taurus
3.1.1.7 3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
 Electrophorus electricus
3.1.1.7 4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 4-chlorophenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 4-chlorophenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 additional information some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin Bos taurus
3.1.1.7 additional information some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin Electrophorus electricus
3.1.1.7 phenyl 1,2-dimethylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 phenyl 1,2-dimethylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 phenyl 1-methylhydrazinecarboxylate
-
 Bos taurus
3.1.1.7 phenyl 1-methylhydrazinecarboxylate
-
 Electrophorus electricus
3.1.1.7 rivastigmin
-
 Bos taurus
3.1.1.7 rivastigmin
-
 Electrophorus electricus
3.1.1.7 sevin
-
 Bos taurus
3.1.1.7 sevin
-
 Electrophorus electricus
3.1.1.8 2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 2-chlorophenyl 1-methylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 3-chlorophenyl 1-methylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates inhibit quickly by carbamoylation Equus caballus
3.1.1.8 3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
 Equus caballus
3.1.1.8 3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
 Equus caballus
3.1.1.8 3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
 Equus caballus
3.1.1.8 3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
 Equus caballus
3.1.1.8 3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
 Equus caballus
3.1.1.8 4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 4-chlorophenyl 1-methylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 galantamin
-
 Equus caballus
3.1.1.8 additional information some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin Equus caballus
3.1.1.8 phenyl 1,2-dimethylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 phenyl 1-methylhydrazinecarboxylate
-
 Equus caballus
3.1.1.8 rivastigmin
-
 Equus caballus
3.1.1.8 sevin
-
 Equus caballus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.8 extracellular
-
 Equus caballus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Bos taurus
-
 choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O Electrophorus electricus
-
 choline + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Bos taurus
-
-
-
3.1.1.7 Electrophorus electricus
-
-
-
3.1.1.8 Equus caballus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 erythrocyte
-
 Bos taurus
-
3.1.1.7 erythrocyte
-
 Electrophorus electricus
-
3.1.1.8 blood plasma
-
 Equus caballus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.7 3.5
-
-
 Bos taurus
3.1.1.7 3.5
-
-
 Electrophorus electricus
3.1.1.8 3.5
-
-
 Equus caballus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Bos taurus choline + acetate
-
 ?
3.1.1.7 acetylcholine + H2O
-
 Electrophorus electricus choline + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Bos taurus thiocholine + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Electrophorus electricus thiocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Bos taurus
3.1.1.7 AChE
-
 Electrophorus electricus
3.1.1.8 BChE
-
 Equus caballus
3.1.1.8 butyrylcholinesterase
-
 Equus caballus
3.1.1.8 cholinesterase
-
 Equus caballus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 25
-
 assay at Bos taurus
3.1.1.7 25
-
 assay at Electrophorus electricus
3.1.1.8 25
-
 assay at Equus caballus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 8
-
 assay at Bos taurus
3.1.1.7 8
-
 assay at Electrophorus electricus
3.1.1.8 8
-
 assay at Equus caballus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 additional information
-
 additional information inhibition kinetics, value of carbamoylation inhibition Bos taurus
3.1.1.7 additional information
-
 additional information inhibition kinetics, value of carbamoylation inhibition Electrophorus electricus
3.1.1.8 additional information
-
 additional information inhibition kinetics, value of carbamoylation inhibition Equus caballus