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Literature summary extracted from

  • Symons, A.; Beinke, S.; Ley, S.C.
    MAP kinase kinase kinases and innate immunity (2006), Trends Immunol., 27, 40-48.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.25 CpG ASK1, TAK1, MEKK3 Mus musculus
2.7.11.25 H2O2 ASK1 Mus musculus
2.7.11.25 interleukin 1 TPL-2, TAK1, MEKK1 and MEKK3 Mus musculus
2.7.11.25 lipopolysaccharide ASK1, TPL-2, TAK1, MEKK1 and MEKK3 Mus musculus
2.7.11.25 protein CD40 TPL-2 Mus musculus
2.7.11.25 protein PGN ASK1 Mus musculus
2.7.11.25 protein pI:C ASK1 Mus musculus
2.7.11.25 protein TAB1 positively regulates TAK1 activity Mus musculus
2.7.11.25 protein TAB2 positively regulates TAK1 activity Mus musculus
2.7.11.25 protein TNF ASK1, TPL-2, MLK3, TAK1, MEKK1 and MEKK3 Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.25 TAK1 expressed in HeLa cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.25 additional information ASK1-/- cells, are resistant to TNF-induced apoptosis, produce low levels of TNF after LPS injection and are resistant to LPS-induced septic shock. In macrophages from TPL-2 deficient mice, activation of ERK is blocked following TLR4, TLR2 or TNFR1 stimulation, whereas activation of p38 and JNK via these receptors is unaffected, LPS upregulation of TNF is reduced, are resistant to endotoxin shock induced by LPS and D-galactosamine. TAK1-/- mice die early in uterus. Mlk3-/- mice are viable. In Mekk1-/- mice, normal or blocked JNK activation induced by TNF and IL-1, discrepancy in two different studies. MEKK3-deficient mice, embryonic lethal, activation of JNK and p38 is blocked, but not of ERK by IL-1 and TLR4 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.25 p105 blocks the ability of TPL-2 to interact with and phosphorylate MEk Mus musculus
2.7.11.25 p38 negatively regulates tAK1 activation Mus musculus
2.7.11.25 RNAi
-
 Homo sapiens
2.7.11.25 RNAi knockdown of TAK1 impairs p38 and JNK activation by IL-1 and TNF Mus musculus
2.7.11.25 thioredoxin ASK1 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Drosophila melanogaster
-
-
-
2.7.11.25 Homo sapiens
-
-
-
2.7.11.25 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.25 B-cell TPL-2, TAK1 Mus musculus
-
2.7.11.25 dendritic cell ASK1 Mus musculus
-
2.7.11.25 fibroblast
-
 Homo sapiens
-
2.7.11.25 HeLa cell TAK1 Homo sapiens
-
2.7.11.25 JURKAT cell MLK3 Homo sapiens
-
2.7.11.25 macrophage TPL-2 and MEKK1 Mus musculus
-
2.7.11.25 MEF cell ASK1, TPL-2, MLK3, TAK1, MEKK1 and MEKK3 Mus musculus
-
2.7.11.25 SCHNEIDER-2 cell TAK1 Drosophila melanogaster
-
2.7.11.25 splenocyte ASK1 Mus musculus
-
2.7.11.25 uterus TAK1 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + ERK
-
 Drosophila melanogaster ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + ERK
-
 Homo sapiens ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + ERK TPL-2, TAK1, MEKK3 Mus musculus ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + JNK
-
 Drosophila melanogaster ADP + phosphorylated JNK
-
 ?
2.7.11.25 ATP + JNK
-
 Homo sapiens ADP + phosphorylated JNK
-
 ?
2.7.11.25 ATP + JNK ASK1, TPL-2, TAK1, MLK3, MEKK3 Mus musculus ADP + phosphorylated JNK
-
 ?
2.7.11.25 ATP + MKK3 ASK1 Mus musculus ADP + phosphorylated MKK3
-
 ?
2.7.11.25 ATP + MKK4 ASK1 Mus musculus ADP + phosphorylated MKK4
-
 ?
2.7.11.25 ATP + MKK6 ASK1, TAK1 Mus musculus ADP + phosphorylated MKK6
-
 ?
2.7.11.25 ATP + p38
-
 Drosophila melanogaster ADP + phosphorylated p38
-
 ?
2.7.11.25 ATP + p38
-
 Homo sapiens ADP + phosphorylated p38
-
 ?
2.7.11.25 ATP + p38 ASK1, TAK1 Mus musculus ADP + phosphorylated p38
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 A-Raf
-
 Mus musculus
2.7.11.25 apoptosis signal-regulating kinase 1
-
 Mus musculus
2.7.11.25 ASK1
-
 Mus musculus
2.7.11.25 B-Raf
-
 Mus musculus
2.7.11.25 DLK
-
 Mus musculus
2.7.11.25 LZK
-
 Mus musculus
2.7.11.25 MAP 3-kinase
-
 Drosophila melanogaster
2.7.11.25 MAP 3-kinase
-
 Mus musculus
2.7.11.25 MAP 3-kinase
-
 Homo sapiens
2.7.11.25 MAP kinase kinase kinase
-
 Drosophila melanogaster
2.7.11.25 MAP kinase kinase kinase
-
 Mus musculus
2.7.11.25 MAP kinase kinase kinase
-
 Homo sapiens
2.7.11.25 MAP3K6
-
 Mus musculus
2.7.11.25 MEK kinase 1
-
 Mus musculus
2.7.11.25 MEK kinase 3
-
 Mus musculus
2.7.11.25 MEKK1
-
 Mus musculus
2.7.11.25 MEKK2
-
 Mus musculus
2.7.11.25 MEKK3
-
 Mus musculus
2.7.11.25 MEKK4
-
 Mus musculus
2.7.11.25 MLK1
-
 Mus musculus
2.7.11.25 MLK2
-
 Mus musculus
2.7.11.25 MLK3
-
 Drosophila melanogaster
2.7.11.25 MLK3
-
 Mus musculus
2.7.11.25 MLK3
-
 Homo sapiens
2.7.11.25 MLK4
-
 Mus musculus
2.7.11.25 Mos
-
 Mus musculus
2.7.11.25 Raf-1
-
 Mus musculus
2.7.11.25 TAK1
-
 Drosophila melanogaster
2.7.11.25 TAK1
-
 Mus musculus
2.7.11.25 TAK1
-
 Homo sapiens
2.7.11.25 TAO1-2
-
 Mus musculus
2.7.11.25 TPL-2
-
 Mus musculus
2.7.11.25 transforming growth factor beta-activated kinase 1
-
 Drosophila melanogaster
2.7.11.25 transforming growth factor beta-activated kinase 1
-
 Mus musculus
2.7.11.25 transforming growth factor beta-activated kinase 1
-
 Homo sapiens
2.7.11.25 tumour progression locus 2
-
 Mus musculus
2.7.11.25 ZAK
-
 Mus musculus