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Literature summary extracted from

  • Murphy, L.O.; Blenis, J.
    MAPK signal specificity: the right place at the right time (2006), Trends Biochem. Sci., 31, 268-275.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 Epidermal growth factor induces potent transient activation of the ERK pathway Rattus norvegicus
2.7.11.24 Insulin causes weak activation Rattus norvegicus
2.7.11.24 additional information cell-surface receptor density, expression of scaffolding proteins, the surrounding extracellular matrix, and the interplay between kinases and phosphatases modulate the strength and duration of ERK signaling, c-Fos transcription factor can function as a sensor for ERK activation dynamics Rattus norvegicus
2.7.11.24 additional information ERK activation in oocytes can be bistable or irreversible owing to a strong positive feedback loop regulated by the Mos kinase Xenopus sp.
2.7.11.24 nerve growth factor alters outcome of ERK signaling Rattus norvegicus
2.7.11.24 Ras essential for ERK activation, the three isoforms N-Ras, K-Ras and H-Ras have an important role in spatial and temporal ERK signaling Rattus norvegicus

Application

EC Number Application Comment Organism
2.7.11.24 medicine ERK signaling is involved in cell cycle progression, cellular transformation and differentation. Spatial distribution and temporal qualities of ERK can markedly alter the qualitative and quantitative features of downstream signaling to immediate early genes and the expression of immediate early genes-encoded protein products. Targeting of ERK/DEF domain signaling axis may be beneficial in many cancers Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 MKP1/2 may dampen ERK activity during the G1/S transition, is involved in reducing strength and duration of ERK signaling Rattus norvegicus
2.7.11.24 MKP3 selective for ERK1 and 2 Rattus norvegicus
2.7.11.24 additional information genes encoding Sef prevent dissociation of the MEK-ERK complex, thereby inhibiting translocation of ERK to the nucleus, but ERK can still signal to cytoplasmic targets Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.24 cytoplasm
-
 Rattus norvegicus 5737
-
2.7.11.24 nucleus
-
 Rattus norvegicus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Rattus norvegicus
-
-
-
2.7.11.24 Xenopus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 oocyte
-
 Xenopus sp.
-
2.7.11.24 PC-12 cell activation of ERK signaling precedes differentiation of PC12 pheochromocytoma cells into sympathetic-like neurons Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + Elk1
-
 Rattus norvegicus ADP + phosphorylated Elk1
-
 ?
2.7.11.24 ATP + JunD
-
 Rattus norvegicus ADP + phosphorylated JunD
-
 ?
2.7.11.24 ATP + MEK
-
 Rattus norvegicus ADP + phosphorylated MEK binding to ERK requires docking domain and the kinase interaction motif ?
2.7.11.24 ATP + RSK
-
 Rattus norvegicus ADP + phosphorylated RSK binding to ERK requires docking domain ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 ERK
-
 Xenopus sp.
2.7.11.24 ERK1
-
 Rattus norvegicus
2.7.11.24 ERK2
-
 Rattus norvegicus
2.7.11.24 extracellular signal-regulated kinase
-
 Rattus norvegicus
2.7.11.24 extracellular signal-regulated kinase
-
 Xenopus sp.