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Literature summary extracted from

  • Melnick, J.G.; Parkin, G.
    Cleaving mercury-alkyl bonds: a functional model for mercury detoxification by MerB (2007), Science, 317, 225-227.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.99.1.2 environmental protection detoxification of organomercury compounds is of critical importance. The bioorganometallic chemistry of mercury in a sulfur-rich coordination environment is studied in order emulate the structure and function of MerB. One of the three non-structural cysteine residues of MerB that are crucial for enzymatic activity is required to coordinate [HgR]+ in a linear manner, a second cysteine is required to activate the Hg-alkyl group toward protolytic cleavage, and the third cysteine is required to effect the cleavage reaction. Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.99.1.2 Escherichia coli
-
-
-
4.99.1.2 Escherichia coli R831b
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.99.1.2 RHg+ + H+
-
Escherichia coli RH + Hg2+
-
?
4.99.1.2 RHg+ + H+
-
Escherichia coli R831b RH + Hg2+
-
?

Synonyms

EC Number Synonyms Comment Organism
4.99.1.2 alkylmercury mercuric-lyase
-
Escherichia coli
4.99.1.2 merB
-
Escherichia coli
4.99.1.2 organomercurial lyase
-
Escherichia coli