Literature summary extracted from

Ghosh, K.S.; Maiti, T.K.; Debnath, J.; Dasgupta, S.
Inhibition of ribonuclease A by polyphenols present in green tea (2007), Proteins, 69, 566-580.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.6.1.18	epicatechin	0.04 mM, 4.4% inhibition, noncompetitve, CD spectral analysis of complex with enzyme, preferred site of binding is around residues 34-39 with possible hydrogen bonding to K7 and R10	Bos taurus
4.6.1.18	epicatechin gallate	0.04 mM, 12.7% inhibition, noncompetitve, CD spectral analysis of complex with enzyme, preferred site of binding is around residues 34-39 with possible hydrogen bonding to K7 and R10	Bos taurus
4.6.1.18	epigallocatechin	0.04 mM, 6.9% inhibition, noncompetitve, CD spectral analysis of complex with enzyme, preferred site of binding is around residues 34-39 with possible hydrogen bonding to K7 and R10	Bos taurus
4.6.1.18	epigallocatechin gallate	0.04 mM, 18.4% inhibition, noncompetitve, CD spectral analysis of complex with enzyme, preferred site of binding is around residues 34-39 with possible hydrogen bonding to K7 and R10	Bos taurus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.6.1.18	Bos taurus	P61823	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.6.1.18	pancreas	-	Bos taurus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)