Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Englebienne, P.; Fiaux, H.; Kuntz, D.A.; Corbeil, C.R.; Gerber-Lemaire, S.; Rose, D.R.; Moitessier, N.
    Evaluation of docking programs for predicting binding of Golgi alpha-mannosidase II inhibitors: a comparison with crystallography (2007), Proteins, 69, 160-176.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.114 medicine promising target for drug development in anti-tumor therapies, ability of seven available docking programs to predict the binding mode and binding affinity of alpha-mannosidase II inhibitors Drosophila melanogaster

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.2.1.114 GMII complexed with inhibitors (2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol, (2R,3R,4S)-2-([[(1S)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol, and (2R,3R,4S,5R)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-5-methylpyrrolidine-3,4-diol, to 1.30-1.45 A resolution Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.114 (1S,2R,6R,7R,8S,8aS)-octahydroindolizine-1,2,6,7,8-pentol most active Drosophila melanogaster
3.2.1.114 (2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol
-
 Drosophila melanogaster
3.2.1.114 (2R,3R,4R,5R)-5-amino-2-(hydroxymethyl)piperidine-3,4-diol
-
 Drosophila melanogaster
3.2.1.114 (2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
-
 Drosophila melanogaster
3.2.1.114 (2R,3R,4S)-2-([[(1S)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
-
 Drosophila melanogaster
3.2.1.114 (2R,3R,4S,5R)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-5-methylpyrrolidine-3,4-diol
-
 Drosophila melanogaster
3.2.1.114 (2R,3R,4S,5S)-6-amino-2-(hydroxymethyl)-2,3,4,5-tetrahydropyridine-3,4,5-triol
-
 Drosophila melanogaster
3.2.1.114 (2R,3S,4R)-2-[(1R)-1-hydroxyethyl]pyrrolidine-3,4-diol most active Drosophila melanogaster
3.2.1.114 (2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-(sulfooxy)butyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
-
 Drosophila melanogaster
3.2.1.114 (3R,4R)-4-aminopyrrolidin-3-ol
-
 Drosophila melanogaster
3.2.1.114 (5R,6R,7S,8R)-5-methyl-1,5,6,7,8,8a-hexahydrotetrazolo[1,5-a]pyridine-6,7,8-triol
-
 Drosophila melanogaster
3.2.1.114 (5R,6R,7S,8S)-5-(hydroxymethyl)-1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-6,7,8-triol
-
 Drosophila melanogaster
3.2.1.114 5-thio-alpha-D-mannopyranosylamine
-
 Drosophila melanogaster
3.2.1.114 kifunensine
-
 Drosophila melanogaster
3.2.1.114 N-[(R)-amino(phenyl)methyl]-5-thio-alpha-D-mannopyranosylamine
-
 Drosophila melanogaster
3.2.1.114 salacinol
-
 Drosophila melanogaster
3.2.1.114 swainsonine most active Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.2.1.114 Zn2+ is involved in the catalytic activity of the enzyme and in the strong binding of inhibitors Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.114 Drosophila melanogaster Q24451
-
-

Synonyms

EC Number Synonyms Comment Organism
3.2.1.114 GmII
-
 Drosophila melanogaster
3.2.1.114 Golgi alpha-mannosidase II
-
 Drosophila melanogaster

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.114 0.000017
-
-
 Drosophila melanogaster swainsonine
3.2.1.114 0.72
-
-
 Drosophila melanogaster (2R,3R,4S)-2-([[(1S)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
3.2.1.114 0.8
-
-
 Drosophila melanogaster (2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol
3.2.1.114 1
-
-
 Drosophila melanogaster (2R,3R,4S,5R)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-5-methylpyrrolidine-3,4-diol