Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, C.D.; Podvin, S.; Gillespie, E.; Leeman, S.E.; Abraham, C.R.
    Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17 (2007), Proc. Natl. Acad. Sci. USA, 104, 19796-19801.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.81 Insulin 0.001 mM, stimulates the cleavage of the extracellular domain of Klotho Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.81 EDTA 10 mM Homo sapiens
3.4.24.81 EGTA 10 mM Homo sapiens
3.4.24.81 additional information TMP-1 and TIMP-2 do not inhibit shedding of Klotho by ADAM10 Homo sapiens
3.4.24.81 TAPI-1 0.05 mM Homo sapiens
3.4.24.81 TIMP-3
-
 Homo sapiens
3.4.24.81 Wortmannin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.81 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.81 extracellular domain of Klotho + H2O
-
 Homo sapiens 130000 Da Klotho fragment + 68000 Da Klotho fragment
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.81 a disintegrin and metalloproteinase 10
-
 Homo sapiens
3.4.24.81 ADAM10
-
 Homo sapiens