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Literature summary extracted from

  • Shu, S.; Mahadeo, D.C.; Liu, X.; Liu, W.; Parent, C.A.; Korn, E.D.
    S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration (2006), Proc. Natl. Acad. Sci. USA, 103, 19788-19793.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 tubercidin inhibition of enzyme as well as of chemotaxis and chemotaxis-dependent cell streaming Dictyostelium discoideum
3.13.2.1 tubercidin inhibition of enzyme as well as of chemotaxis, at concentrations that have little effect on cell viability Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.13.2.1 cytoplasm diffuse in nonmotile amoebae. Concentration with F-actin in pseudopods at the front of motile, chemotaxing cells, but not present in filopodia or at the very leading edge Homo sapiens 5737
-
3.13.2.1 cytoplasm diffuse in nonmotile amoebae. Concentration with F-actin in pseudopods at the front of motile, chemotaxing cells, but not present in filopodia or at the very leading edge Dictyostelium discoideum 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 additional information Homo sapiens enzyme redistributes in response to chemotactic signals ?
-
 ?
3.13.2.1 additional information Dictyostelium discoideum enzyme redistributes in response to chemotactic signals ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Dictyostelium discoideum
-
-
-
3.13.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 additional information enzyme redistributes in response to chemotactic signals Homo sapiens ?
-
 ?
3.13.2.1 additional information enzyme redistributes in response to chemotactic signals Dictyostelium discoideum ?
-
 ?