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Literature summary extracted from

  • Jukic, M.; Politeo, O.; Maksimovic, M.; Milos, M.; Milos, M.
    In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone (2007), Phytother. Res., 21, 259-261.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 carvacrol in vitro inhibition, compound of the essential oil of Thymus vulgaris Electrophorus electricus
3.1.1.7 galanthamine
-
 Electrophorus electricus
3.1.1.7 linalool weak in vitro inhibition Electrophorus electricus
3.1.1.7 additional information the enzyme is not affected by ethanol concentrations up to 500 mM Electrophorus electricus
3.1.1.7 thyme essential oil
-
 Electrophorus electricus
3.1.1.7 thymohydroquinone high in vitro inhibition, compound of the essential oil of Thymus vulgaris Electrophorus electricus
3.1.1.7 Thymol in vitro inhibition, compound of the essential oil of Thymus vulgaris Electrophorus electricus
3.1.1.7 thymoquinone in vitro inhibition, compound of the essential oil of Thymus vulgaris Electrophorus electricus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Electrophorus electricus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 alpha-naphthyl acetate + H2O
-
 Electrophorus electricus 1-naphthol + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 37
-
 assay at Electrophorus electricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.8
-
 assay at Electrophorus electricus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.00025
-
 pH 7.8, 37°C Electrophorus electricus galanthamine
3.1.1.7 0.04
-
 pH 7.8, 37°C Electrophorus electricus thymohydroquinone
3.1.1.7 0.063
-
 pH 7.8, 37°C Electrophorus electricus carvacrol
3.1.1.7 0.14
-
 pH 7.8, 37°C Electrophorus electricus thymoquinone
3.1.1.7 0.54
-
 pH 7.8, 37°C Electrophorus electricus thyme essential oil
3.1.1.7 0.74
-
 pH 7.8, 37°C Electrophorus electricus Thymol