EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B14 | expressed in S2 cells | Drosophila melanogaster |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B14 | phosphoramidon | - |
Drosophila melanogaster | |
3.4.24.B14 | thiorphan | - |
Drosophila melanogaster |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.B14 | cytoplasm | - |
Drosophila melanogaster | 5737 | - |
3.4.24.B14 | membrane | - |
Drosophila melanogaster | 16020 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.B14 | 83000 | - |
deglycosylated enzyme, SDS-PAGE | Drosophila melanogaster |
3.4.24.B14 | 100000 | - |
soluble enzyme, SDS-PAGE | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B14 | Drosophila melanogaster | - |
- |
- |
3.4.24.B14 | Drosophila melanogaster OregonR | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.B14 | glycoprotein | - |
Drosophila melanogaster |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.24.B14 | Phenyl-Sepharose column chromatography and HiTrap Q HP column chromatography | Drosophila melanogaster |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.B14 | embryo | - |
Drosophila melanogaster | - |
3.4.24.B14 | malpighian tubule | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B14 | Drosophila tachykinin-1 + H2O | 3% activity compared to Locusta tachykinin-1 | Drosophila melanogaster | APTSS + FIGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-1 + H2O | 3% activity compared to Locusta tachykinin-1 | Drosophila melanogaster OregonR | APTSS + FIGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-2 + H2O | 33% activity compared to Locusta tachykinin-1 | Drosophila melanogaster | APLAFYG + Leu-Arg-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-2 + H2O | 33% activity compared to Locusta tachykinin-1 | Drosophila melanogaster OregonR | APLAFYG + Leu-Arg-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-3 + H2O | 1% activity compared to Locusta tachykinin-1 | Drosophila melanogaster | APTG + FTGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-3 + H2O | 1% activity compared to Locusta tachykinin-1 | Drosophila melanogaster OregonR | APTG + FTGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-4 + H2O | 8% activity compared to Locusta tachykinin-1 | Drosophila melanogaster | APVNS + FVGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-4 + H2O | 8% activity compared to Locusta tachykinin-1 | Drosophila melanogaster OregonR | APVNS + FVGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-5 + H2O | 2% activity compared to Locusta tachykinin-1 | Drosophila melanogaster | APNG + FLGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-5 + H2O | 2% activity compared to Locusta tachykinin-1 | Drosophila melanogaster OregonR | APNG + FLGMR-amide | - |
? | |
3.4.24.B14 | Drosophila tachykinin-6 + H2O | 17% activity compared to Locusta tachykinin-1 | Drosophila melanogaster | QQR + Phe + ADFNSKFVAVR-amide | - |
? | |
3.4.24.B14 | Locusta tachykinin-1 + H2O | 100% activity | Drosophila melanogaster | GPSGFYG + Val-amide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B14 | NEP2 | - |
Drosophila melanogaster |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.B14 | 7 | 7.5 | - |
Drosophila melanogaster |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.B14 | 6.5 | 8 | activity is drastically reduced below pH 6.5 and above pH 8.0 | Drosophila melanogaster |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.24.B14 | 0.0005 | - |
membrane-bound enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C | Drosophila melanogaster | thiorphan | |
3.4.24.B14 | 0.002 | - |
soluble enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C | Drosophila melanogaster | phosphoramidon | |
3.4.24.B14 | 0.003 | - |
membrane-bound enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C | Drosophila melanogaster | phosphoramidon | |
3.4.24.B14 | 0.08 | - |
soluble enzyme, in 0.1 M HEPES, 0.01 mM captopril, at pH 7 and 35°C | Drosophila melanogaster | thiorphan |