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Literature summary extracted from

  • Vanegas, G.; Quinones, W.; Carrasco-Lopez, C.; Concepcion, J.L.; Albericio, F.; Avilan, L.
    Enolase as a plasminogen binding protein in Leishmania mexicana (2007), Parasitol. Res., 101, 1511-1516.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.11 additional information antibodies against enolase inhibits up to 60% of plasminogen binding Leishmania mexicana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.11 cytosol microsomal fraction analyzed Leishmania mexicana 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.11 2-phospho-D-glycerate Leishmania mexicana
-
 phosphoenolpyruvate + H2O
-
 r
4.2.1.11 2-phospho-D-glycerate Leishmania mexicana AZV
-
 phosphoenolpyruvate + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.11 Leishmania mexicana Q3HL75
-
-
4.2.1.11 Leishmania mexicana AZV Q3HL75
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.11 recombinant protein Leishmania mexicana

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.11 promastigote for in vivo binding studies to human plasminogen Leishmania mexicana
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.2.1.11 additional information
-
 recombinant enolase has plasminogen binding activity, similarities to nine amino-acid internal plasminogen-binding motif of Streptococcus pneumoniae, enolase as one of the plasminogen receptors in the parasite predicted Leishmania mexicana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.11 2-phospho-D-glycerate
-
 Leishmania mexicana phosphoenolpyruvate + H2O
-
 r
4.2.1.11 2-phospho-D-glycerate
-
 Leishmania mexicana AZV phosphoenolpyruvate + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.11 enolase
-
 Leishmania mexicana