BRENDA - Enzyme Database

Enolase as a plasminogen binding protein in Leishmania mexicana

Vanegas, G.; Quinones, W.; Carrasco-Lopez, C.; Concepcion, J.L.; Albericio, F.; Avilan, L.; Parasitol. Res. 101, 1511-1516 (2007)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.11
additional information
antibodies against enolase inhibits up to 60% of plasminogen binding
Leishmania mexicana
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.11
cytosol
microsomal fraction analyzed
Leishmania mexicana
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.11
2-phospho-D-glycerate
Leishmania mexicana
-
phosphoenolpyruvate + H2O
-
-
r
4.2.1.11
2-phospho-D-glycerate
Leishmania mexicana AZV
-
phosphoenolpyruvate + H2O
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.11
Leishmania mexicana
Q3HL75
-
-
4.2.1.11
Leishmania mexicana AZV
Q3HL75
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.1.11
recombinant protein
Leishmania mexicana
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.11
promastigote
for in vivo binding studies to human plasminogen
Leishmania mexicana
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
4.2.1.11
additional information
-
recombinant enolase has plasminogen binding activity, similarities to nine amino-acid internal plasminogen-binding motif of Streptococcus pneumoniae, enolase as one of the plasminogen receptors in the parasite predicted
Leishmania mexicana
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.11
2-phospho-D-glycerate
-
682238
Leishmania mexicana
phosphoenolpyruvate + H2O
-
-
-
r
4.2.1.11
2-phospho-D-glycerate
-
682238
Leishmania mexicana AZV
phosphoenolpyruvate + H2O
-
-
-
r
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.11
additional information
antibodies against enolase inhibits up to 60% of plasminogen binding
Leishmania mexicana
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.11
cytosol
microsomal fraction analyzed
Leishmania mexicana
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.11
2-phospho-D-glycerate
Leishmania mexicana
-
phosphoenolpyruvate + H2O
-
-
r
4.2.1.11
2-phospho-D-glycerate
Leishmania mexicana AZV
-
phosphoenolpyruvate + H2O
-
-
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.11
recombinant protein
Leishmania mexicana
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.11
promastigote
for in vivo binding studies to human plasminogen
Leishmania mexicana
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
4.2.1.11
additional information
-
recombinant enolase has plasminogen binding activity, similarities to nine amino-acid internal plasminogen-binding motif of Streptococcus pneumoniae, enolase as one of the plasminogen receptors in the parasite predicted
Leishmania mexicana
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.11
2-phospho-D-glycerate
-
682238
Leishmania mexicana
phosphoenolpyruvate + H2O
-
-
-
r
4.2.1.11
2-phospho-D-glycerate
-
682238
Leishmania mexicana AZV
phosphoenolpyruvate + H2O
-
-
-
r