EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.1 | colcemid | microtubule inhibitor, arrests cells in M phase, followed by induction of apotosis, 1 and 5 ng/ml colcemid display only modest cytotoxic effects. 10, 50 and 100 ng/ml induce pronounced cell death as measured by flow cytometry analysis | Homo sapiens | |
5.6.2.1 | additional information | tumor suppressor p53 not only plays a key role in the regulation of the htopoI response to UV-C irradiation but also to treatment with colcemid | Homo sapiens | |
5.6.2.1 | Tumor necrosis factor alpha | TNFalpha induces receptor-mediated apotosis. Receptor-mediated apoptosis induced by TNFalpha results in a very strong htopoI damage response, further indicating a general involvement of htopoI in apoptosis | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.1 | Homo sapiens | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.6.2.1 | hTopoI | - |
Homo sapiens |
5.6.2.1 | Topoisomerase I | - |
Homo sapiens |