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Literature summary extracted from

  • Obeid, D.; Nguyen, J.; Lesavre, P.; Bauvois, B.
    Differential regulation of tumor necrosis factor-alpha-converting enzyme and angiotensin-converting enzyme by type I and II interferons in human normal and leukemic myeloid cells (2007), Oncogene, 26, 102-110.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 additional information no apparent change in mRNA contents of TACE upon stimulation with IFN alpha, IFN beta and IFN gamma Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 cytoplasm TACE is located in the cytoplasm of IFN gamma-treated cells Homo sapiens 5737
-
3.4.24.86 plasma membrane
-
Homo sapiens 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 marrow cell
-
Homo sapiens
-
3.4.24.86 monocyte
-
Homo sapiens
-
3.4.24.86 NB-4 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 amyloid-protein precursor + H2O
-
Homo sapiens ?
-
?
3.4.24.86 intercellular cell adhesion molecule-1 + H2O
-
Homo sapiens ?
-
?
3.4.24.86 p75 tumour necrosis factor receptor + H2O
-
Homo sapiens ?
-
?
3.4.24.86 proTNF-alpha + H2O
-
Homo sapiens soluble TNF-alpha
-
?
3.4.24.86 transforming growth factor-alpha + H2O
-
Homo sapiens ?
-
?
3.4.24.86 vascular cellular adhesion molecule-1 + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM-17
-
Homo sapiens
3.4.24.86 CD156
-
Homo sapiens
3.4.24.86 TACE
-
Homo sapiens
3.4.24.86 tumor necrosis factor-alpha-converting enzyme
-
Homo sapiens