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Literature summary extracted from

  • Wojcik, M.; Cieslak, M.; Stec, W.J.; Goding, J.W.; Koziolkiewicz, M.
    Nucleotide pyrophosphatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleotides (2007), Oligonucleotides, 17, 134-145.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.16.1 Ap4A
-
Homo sapiens
3.1.16.1 ATP
-
Homo sapiens
3.1.16.1 ATPgammaS
-
Homo sapiens
3.1.16.1 heparin
-
Homo sapiens
3.1.16.1 additional information no inhibition up to 40 mM by lysophosphatidylcholine Homo sapiens
3.1.16.1 p-nitrophenyl-TMP
-
Homo sapiens
3.1.16.1 pyridoxal 5'phosphate-6-azophenyl-2',4'-disulfonic acid
-
Homo sapiens
3.1.16.1 RP-dATPalphaS
-
Homo sapiens
3.1.16.1 SP-ATPalphaS
-
Homo sapiens
3.1.16.1 SP-CTPalphaS
-
Homo sapiens
3.1.16.1 SP-dATPalphaS
-
Homo sapiens
3.1.16.1 UDP-glucose
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.16.1 0.016
-
[S]-d[T12]
-
Homo sapiens
3.1.16.1 0.0715
-
[S]-d[A12]
-
Homo sapiens
3.1.16.1 0.173
-
[RP-PS]-d[T12]
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.16.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.16.1 plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.16.1 additional information [RP-but last one-PS]-d[T12] is not hydrolyzed Homo sapiens ?
-
?
3.1.16.1 [PO/Mix-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O 21% degraded after 2 hours, 35% degraded after 8 hours Homo sapiens ?
-
?
3.1.16.1 [PO/Mix-PS]-d[TPOTPOTPOTPOTPOTPOTPOTPOTPOTPOTPST] + H2O 35% degraded after 2 hours, 75% degraded after 8 hours Homo sapiens ?
-
?
3.1.16.1 [PO/RP-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O 22% degraded after 2 hours, 45% degraded after 8 hours Homo sapiens ?
-
?
3.1.16.1 [PO/SP-PS]-d[TPOCPOTPOTPOTPOTPOTPSC] + H2O 20% degraded after 2 hours, 25% degraded after 8 hours Homo sapiens ?
-
?
3.1.16.1 [PS]-d[A6] + H2O
-
Homo sapiens ?
-
?
3.1.16.1 [RP-PS]-d[A12] + H2O
-
Homo sapiens ?
-
?
3.1.16.1 [RP-PS]-d[T12] + H2O 25% degraded after 2 hours, 75% degraded after 8 hours Homo sapiens ?
-
?
3.1.16.1 [S]-d[A12] + H2O
-
Homo sapiens ?
-
?
3.1.16.1 [S]-d[T12] + H2O 100% degraded after 2 hours Homo sapiens ?
-
?
3.1.16.1 [S]-d[TCCTCTTTTTTT] + H2O
-
Homo sapiens ?
-
?
3.1.16.1 [S]-d[TCTTTTTC] + H2O 100% degraded after 2 hours Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.16.1 3'-exonuclease
-
Homo sapiens
3.1.16.1 More EC3.1.4.1/EC 3.6.1.9 Homo sapiens
3.1.16.1 NPP1
-
Homo sapiens
3.1.16.1 nucleotide pyrophosphatase/phosphodiesterase 1
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.16.1 0.0002
-
inhibition of degradation of [RP-PS]-d[A12] Homo sapiens SP-ATPalphaS
3.1.16.1 0.0014
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens SP-ATPalphaS
3.1.16.1 0.0015
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens SP-dATPalphaS
3.1.16.1 0.002
-
inhibition of degradation of [PO]-d[A12] Homo sapiens SP-ATPalphaS
3.1.16.1 0.002
-
inhibition of degradation of [RP-PS]-d[A12] Homo sapiens RP-dATPalphaS
3.1.16.1 0.005
-
inhibition of degradation of [PO]-d[A12] Homo sapiens RP-dATPalphaS
3.1.16.1 0.005
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens RP-dATPalphaS
3.1.16.1 0.0084
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens SP-CTPalphaS
3.1.16.1 0.027
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens ATPgammaS
3.1.16.1 0.027
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens p-nitrophenyl-TMP
3.1.16.1 0.037
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens Ap4A
3.1.16.1 0.054
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens ATP
3.1.16.1 0.071
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens pyridoxal 5'phosphate-6-azophenyl-2',4'-disulfonic acid
3.1.16.1 0.106
-
inhibition of degradation of [PO]-d[TCCTCTTTTTTT] Homo sapiens UDP-glucose