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Literature summary extracted from

  • Kanungo, J.; Li, B.S.; Goswami, M.; Zheng, Y.L.; Ramchandran, R.; Pant, H.C.
    Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5 (2007), Neurosci. Lett., 412, 233-238.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.11.22 additional information zebrafish cdk5 is 96% identical to its human counterpart, Xenopus and most other vertebrate cdk5, the enzyme plays a crucial role in the development of the peripheral nervous system Danio rerio

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.22
-
 Danio rerio

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 siRNA knockdown of cdk5, results in a reduction in primary sensory neurons of the trigeminal ganglia of the peripheral nervous system, 80% loss of cdk5 protein in 10 hpf embryos Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 blastula 2.5 hpf Danio rerio
-
2.7.11.22 brain 24hpf embryos Danio rerio
-
2.7.11.22 embryo at 11.5 h of development, cdk5 transcripts are present in the neural plate at the domains where primary neurons begin to be specified Danio rerio
-
2.7.11.22 eye especially in the lens capsule of 24hpf embryos Danio rerio
-
2.7.11.22 muscle 24hpf embryos Danio rerio
-
2.7.11.22 spinal cord 24hpf embryos Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + histone H1
-
 Danio rerio ADP + phosphorylated histone H1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 Cdk5
-
 Danio rerio
2.7.11.22 cyclin-dependent kinase 5
-
 Danio rerio