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Literature summary extracted from

  • Karsten, S.L.; Sang, T.K.; Gehman, L.T.; Chatterjee, S.; Liu, J.; Lawless, G.M.; Sengupta, S.; Berry, R.W.; Pomakian, J.; Oh, H.S.; Schulz, C.; Hui, K.S.; Wiedau-Pazos, M.; Vinters, H.V.; Binder, L.I.; Geschwind, D.H.; Jackson, G.R.
    A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration (2006), Neuron, 51, 549-560.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.14 expressed in Mus musculus brain Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.14 bestatin
-
 Homo sapiens
3.4.11.14 puromycin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.14 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.14 glutathione-Sepharose column chromatography and Superdex-200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.14 brain cortex
-
 Homo sapiens
-
3.4.11.14 cerebellum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.14 Ala-p-nitroanilide + H2O
-
 Homo sapiens Ala + p-nitroaniline
-
 ?
3.4.11.14 Leu-p-nitroanilide + H2O
-
 Homo sapiens Leu + p-nitroaniline
-
 ?
3.4.11.14 Lys-p-nitroanilide + H2O
-
 Homo sapiens Lys + p-nitroaniline
-
 ?
3.4.11.14 Met-p-nitroanilide + H2O
-
 Homo sapiens Met + p-nitroaniline
-
 ?
3.4.11.14 Pro-p-nitroanilide + H2O
-
 Homo sapiens Pro + p-nitroaniline
-
 ?
3.4.11.14 tau protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.14 Val-p-nitroanilide + H2O
-
 Homo sapiens Val + p-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.14 NPEPPS
-
 Homo sapiens
3.4.11.14 PSA
-
 Homo sapiens
3.4.11.14 puromycin-sensitive aminopeptidase
-
 Homo sapiens