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Literature summary extracted from

  • Kamal, M.A.; Klein, P.; Luo, W.; Li, Y.; Holloway, H.W.; Tweedie, D.; Greig, N.H.
    Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental alzheimer therapeutic, dihydrobenzodioxepine cymserine (2007), Neurochem. Res., 33, 745-753.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 BW284c51 irreversible inhibitor Homo sapiens
3.1.1.8 dihydrobenzodioxepine cymserine i.e. DHBDC Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.8 extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.8 butyrylthiocholine + H2O Homo sapiens BuChE catalyses the hydrolysis of numerous endogenous substances, including choline esters and the growth hormone secretagogue, octanoyl ghrelin and has an important role in Alzheimer’s disease thiocholine + butyrate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 brain
-
Homo sapiens
-
3.1.1.8 serum
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylthiocholine + H2O
-
Homo sapiens thiocholine + butyrate
-
?
3.1.1.8 butyrylthiocholine + H2O BuChE catalyses the hydrolysis of numerous endogenous substances, including choline esters and the growth hormone secretagogue, octanoyl ghrelin and has an important role in Alzheimer’s disease Homo sapiens thiocholine + butyrate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BuChE
-
Homo sapiens
3.1.1.8 butyrylcholinesterase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.8 25
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.8 7.2
-
assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.8 additional information
-
additional information inhibition kinetcis Homo sapiens