Any feedback?
Literature summary extracted from
- Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration (2007), Neurochem. Res., 32, 2062-2071.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.14 | amastatin | - |
Mus musculus |  |
| 3.4.11.14 | amastatin | - |
Rattus norvegicus | |
| 3.4.11.14 | puromycin | - |
Mus musculus | |
| 3.4.11.14 | puromycin | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.14 | 0.00095 | - |
Met-enkephalin | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.11.14 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.4.11.14 | cytosol | 80% of the PSA resides in the cytosol | Mus musculus | 5829 | - |
| 3.4.11.14 | membrane | 20% of the PSA is associated with the membrane | Mus musculus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.14 | Mg2+ | Mg2+ restores the activity of the apoenzyme | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.14 | 110000 | - |
SDS-PAGE | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.14 | Mus musculus | - |
- |
- |
| 3.4.11.14 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.14 | brain | - |
Mus musculus | - |
| 3.4.11.14 | brain | - |
Rattus norvegicus | - |
| 3.4.11.14 | cerebral cortex | - |
Mus musculus | - |
| 3.4.11.14 | hippocampus | - |
Mus musculus | - |
| 3.4.11.14 | hippocampus | - |
Rattus norvegicus | - |
| 3.4.11.14 | hypothalamus | - |
Mus musculus | - |
| 3.4.11.14 | thalamus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.14 | L-Arg-enkephalin + H2O | - |
Mus musculus | L-Arg + enkephalin | - |
? | |
| 3.4.11.14 | Met-enkephalin + H2O | - |
Rattus norvegicus | ? | releases only the N-terminal tyrosine | ? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.11.14 | monomer | 1 * 110000, SDS-PAGE | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.14 | GenePSA-dependent puromycin-sensitive aminopeptidase | - |
Mus musculus |
| 3.4.11.14 | NAP | - |
Mus musculus |
| 3.4.11.14 | NAP | - |
Rattus norvegicus |
| 3.4.11.14 | NPEPPS | - |
Mus musculus |
| 3.4.11.14 | PSA | - |
Mus musculus |
| 3.4.11.14 | puromycin-sensitive aminopeptidase | - |
Mus musculus |
| 3.4.11.14 | puromycin-sensitive neuron-aminopeptidase | - |
Mus musculus |
| 3.4.11.14 | puromycin-sensitive neuron-aminopeptidase | - |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.14 | 7 | - |
- |
Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.11.14 | 0.00004 | - |
amastatin | - |
Rattus norvegicus | |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.11.14 | Rattus norvegicus | isoelectric focusing | - |
5.25 |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
