EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.5 | additional information | glyoxalase I protein amounts are 1.5fold increased in early Alzheimers disease subjects | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
4.4.1.5 | medicine | decrease of glyoxalase I expression with increasing Alzheimers disease stage might be one reason for methylglyoxal-induced neuronal impairment, apoptosis, and advanced glycation end formation in plaques and tangles | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.5 | additional information | reducing glyoxalase I RNA levels with advancing stage of Alzheimers disease and with increasing age, continuously decrease in middle and late stages of Alzheimers disease, glyoxalase I activity neither significantly changes with age nor with the course of the disease | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.4.1.5 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.4.1.5 | brain | Brodmann area 22, glyoxalase I levels are diminished in old aged brains but elevated in Alzheimers disease brains, Brodmann area 28, elevated amounts of advanced glycation end staining and decreased levels of glyoxalase I with advancing stage of Alzheimers disease | Homo sapiens | - |
4.4.1.5 | cerebral cortex | - |
Homo sapiens | - |
4.4.1.5 | neuron | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.5 | glutathione + methylglyoxal | - |
Homo sapiens | S-D-lactoylglutathione | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.4.1.5 | glyoxalase I | - |
Homo sapiens |