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Literature summary extracted from

  • Venditti, J.J.; Donigan, K.A.; Bean, B.S.
    Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm (2007), Mol. Reprod. Dev., 74, 758-766.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.51 additional information cell-bound enzyme activity increases sharply following permeabilization of intact sperm Homo sapiens

Application

EC Number Application Comment Organism
3.2.1.51 medicine has a role in the intimate species signature interactions between sperm and oocyte. Relevance for reproductive function in nature or in assisted reproductive technologies Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.51 deoxyfuconojirimycin inhibits by 94-100% at 1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.51 membrane fucosidase is broadly distributed over the membrane systems of human sperm, but is relatively enriched within the equatorial segment Homo sapiens 16020
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3.2.1.51 membrane is present to some degree in most of the sperm membranes, with a portion detectable on the outer surface of intact sperm. Larger quantities are present within cells, and particularly within the acrosomal compartment, and in the equatorial segment of the human sperm cell Homo sapiens 16020
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Organism

EC Number Organism UniProt Comment Textmining
3.2.1.51 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.51 sperm
-
 Homo sapiens
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3.2.1.51 sperm fucosidase is broadly distributed over the membrane systems of human sperm, but is relatively enriched within the equatorial segment. Cell-bound enzyme activity increases sharply following permeabilization of intact sperm, representing cryptic fucosidase that is relatively stable and corresponds with strong fluorescence in the equatorial segment and other sperm membranes. Fucosidase has a role in the intimate species signature interactions between sperm and oocyte Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.51 4-methylumbelliferyl-alpha-L-fucopyranoside + H2O
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 Homo sapiens 4-methylumbelliferone + alpha-L-fucose
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