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Literature summary extracted from
- Adenylyl cyclases in oocyte maturation: a characterization of AC isoforms in bovine cumulus cells (2006), Mol. Reprod. Dev., 73, 1202-1210.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | BIM-1 | specific protein-kinase C inhibitor, significantly increases cumulus cell cAMP concentrations | Bos taurus |  |
| 4.6.1.1 | clonidine | slight stimulatory effect on cAMP concentrations | Bos taurus | |
| 4.6.1.1 | EGTA | significantly increases cumulus cell cAMP concentrations | Bos taurus | |
| 4.6.1.1 | forskolin | increases substantially cAMP concentrations | Bos taurus | |
| 4.6.1.1 | H89 | specific inhibitor of protein-kinase A, significantly increases cumulus cell cAMP concentrations at 0.0001 and 0.03 mM | Bos taurus | |
| 4.6.1.1 | ionomycin | increases intracellular Ca2+ concentrations, significantly increases cumulus cell cAMP concentrations | Bos taurus | |
| 4.6.1.1 | additional information | cholera toxin, KN-62, phorbol-12-myristate-13-acetate and BAPTA-am or a combination of 3 mM EGTA plus BAPTA-am have no effect on cAMP concentrations | Bos taurus | |
| 4.6.1.1 | pertussis toxin | catalyses ADP-ribosylation of a cysteine residue on GalphaI, causing the G-protein complex to become uncoupled from the receptor, significantly increases cAMP concentrations | Bos taurus | |
| 4.6.1.1 | staurosporine | non-specific protein-kinase C inhibitor, significantly increases cumulus cell cAMP concentrations | Bos taurus | |
| 4.6.1.1 | thapsigargin | increases intracellular Ca2+ concentrations, significantly increases cumulus cell cAMP concentrations | Bos taurus | |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | medicine | cumulus cells possess multiple active isoforms of adenylyl cyclase, each isoform may have a specific role at a specific time during oocyte growth and maturation | Bos taurus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.6.1.1 | membrane | - |
Bos taurus | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | brain | all nine membrane-associated isoforms | Bos taurus | - |
| 4.6.1.1 | granulosa cell | AC isoforms 3, 4, 6, 8, and 9 | Bos taurus | - |
| 4.6.1.1 | additional information | AC isoforms 1, 3, 4, 6, and 9 in cumulus cells. AC1, AC4 and AC6 predominate | Bos taurus | - |
| 4.6.1.1 | ovary | - |
Bos taurus | - |
| 4.6.1.1 | testis | sAC | Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | ATP | - |
Bos taurus | 3',5'-cAMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | AC1 | - |
Bos taurus |
| 4.6.1.1 | AC2 | - |
Bos taurus |
| 4.6.1.1 | AC3 | - |
Bos taurus |
| 4.6.1.1 | AC4 | - |
Bos taurus |
| 4.6.1.1 | AC5 | - |
Bos taurus |
| 4.6.1.1 | AC6 | - |
Bos taurus |
| 4.6.1.1 | AC7 | - |
Bos taurus |
| 4.6.1.1 | AC8 | - |
Bos taurus |
| 4.6.1.1 | AC9 | - |
Bos taurus |
| 4.6.1.1 | adenylate cyclases I | - |
Bos taurus |
| 4.6.1.1 | adenylate cyclases IV | - |
Bos taurus |
| 4.6.1.1 | adenylate cyclases VI | - |
Bos taurus |
| 4.6.1.1 | sAC | - |
Bos taurus |
| 4.6.1.1 | soluble adenylyl cyclase | - |
Bos taurus |
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