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Literature summary extracted from

  • Verbeek, M.M.; Geurtz, P.B.; Willemsen, M.A.; Wevers, R.A.
    Aromatic L-amino acid decarboxylase enzyme activity in deficient patients and heterozygotes (2007), Mol. Genet. Metab., 90, 363-369.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.28 3,4-dihydroxyphenylalanine inhibitory effect of 3,4-dihydroxyphenylalanine on the conversion of 5-hydroxy-L-tryptophan Homo sapiens
4.1.1.28 5-hydroxy indole acetic acid the conversion of 5-hydroxy-L-tryptophan is 20% inhibited by 0.33 mM 5-hydroxy indole acetic acid Homo sapiens
4.1.1.28 5-hydroxy-L-tryptophan strong inhibitory effect of 5-hydroxy-L-tryptophan on the conversion of 3,4-dihydroxyphenylalanine Homo sapiens
4.1.1.28 carbidopa strongly inhibited by increasing concentrations of carbidopa, at a concentration of 0.4 mM carbidopa the conversion of 3,4-dihydroxyphenylalanine is completely inhibited, at a concentration of 0.25 mM the conversion of 5-hydroxy-L-tryptophan is completely inhibited Homo sapiens
4.1.1.28 dopamine the conversion of 5-hydroxy-L-tryptophan is strongly inhibited by dopamine Homo sapiens
4.1.1.28 additional information not inhibited by 3-methoxy-tyrosine, homovanillic acid, or 5-hydroxy-tryptamine Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.28 0.49
-
5-hydroxy-L-tryptophan in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C Homo sapiens
4.1.1.28 0.62
-
3,4-dihydroxyphenylalanine in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.28 plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 3,4-Dihydroxyphenylalanine
-
Homo sapiens Dopamine + CO2
-
?
4.1.1.28 5-hydroxy-L-tryptophan
-
Homo sapiens serotonin + CO2
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 AADC
-
Homo sapiens
4.1.1.28 Aromatic L-amino acid decarboxylase
-
Homo sapiens
4.1.1.28 DOPA decarboxylase
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.28 8
-
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.1.28 0.33
-
inhibits the conversion of 5-hydroxy-L-tryptophan Homo sapiens dopamine