EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.28 | 3,4-dihydroxyphenylalanine | inhibitory effect of 3,4-dihydroxyphenylalanine on the conversion of 5-hydroxy-L-tryptophan | Homo sapiens | |
4.1.1.28 | 5-hydroxy indole acetic acid | the conversion of 5-hydroxy-L-tryptophan is 20% inhibited by 0.33 mM 5-hydroxy indole acetic acid | Homo sapiens | |
4.1.1.28 | 5-hydroxy-L-tryptophan | strong inhibitory effect of 5-hydroxy-L-tryptophan on the conversion of 3,4-dihydroxyphenylalanine | Homo sapiens | |
4.1.1.28 | carbidopa | strongly inhibited by increasing concentrations of carbidopa, at a concentration of 0.4 mM carbidopa the conversion of 3,4-dihydroxyphenylalanine is completely inhibited, at a concentration of 0.25 mM the conversion of 5-hydroxy-L-tryptophan is completely inhibited | Homo sapiens | |
4.1.1.28 | dopamine | the conversion of 5-hydroxy-L-tryptophan is strongly inhibited by dopamine | Homo sapiens | |
4.1.1.28 | additional information | not inhibited by 3-methoxy-tyrosine, homovanillic acid, or 5-hydroxy-tryptamine | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.28 | 0.49 | - |
5-hydroxy-L-tryptophan | in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C | Homo sapiens | |
4.1.1.28 | 0.62 | - |
3,4-dihydroxyphenylalanine | in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.28 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.1.1.28 | plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.28 | 3,4-Dihydroxyphenylalanine | - |
Homo sapiens | Dopamine + CO2 | - |
? | |
4.1.1.28 | 5-hydroxy-L-tryptophan | - |
Homo sapiens | serotonin + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.28 | AADC | - |
Homo sapiens |
4.1.1.28 | Aromatic L-amino acid decarboxylase | - |
Homo sapiens |
4.1.1.28 | DOPA decarboxylase | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.28 | 8 | - |
- |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
4.1.1.28 | 0.33 | - |
inhibits the conversion of 5-hydroxy-L-tryptophan | Homo sapiens | dopamine |