Literature summary extracted from

van Meeteren, L.A.; Ruurs, P.; Stortelers, C.; Bouwman, P.; van Rooijen, M.A.; Pradere, J.P.; Pettit, T.R.; Wakelam, M.J.; Saulnier-Blache, J.S.; Mummery, C.L.; Moolenaar, W.H.; Jonkers, J.
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development (2006), Mol. Cell. Biol., 26, 5015-5022.

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.1.4.39	additional information	experiment with ATX-deficient mice. ATX deficiency is lethal at the embryonic stage	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.39	Mus musculus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.39	lysophosphatidylcholine + H2O	-	Mus musculus	lysophosphatidic acid + choline	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.39	ATX	-	Mus musculus
3.1.4.39	autotaxin	essential for blood vessel formation during development	Mus musculus
3.1.4.39	lysophospholipase D	promotes cell migration, metastasis, and angiogenesis	Mus musculus
3.1.4.39	lysoPLD	-	Mus musculus
3.1.4.39	nucleotide pyrophosphatase-phosphodiesterase	belongs to the nucleotide pyrophosphatase (NPP) family of ectoenzymes and exoenzymes	Mus musculus

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Release 2023.1 (January 2023)