EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B14 | expressed in HEK293 cells | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.11 | thiorphan | - |
Mus musculus | |
3.4.24.B14 | calcium ionophore A23187 | 0.001 mM | Mus musculus | |
3.4.24.B14 | forskolin | 0.01 mM | Mus musculus | |
3.4.24.B14 | additional information | disruption of the Golgi apparatus with brefeldin A markedly reduces extracellular NEP2 activity in parallel with intracellular NEP2 protein level in HEK293 cells; nocodazole and cytochalasin B barely affect NEP2 activity | Mus musculus | |
3.4.24.B14 | thapsigargin | 0.0001 mM | Mus musculus | |
3.4.24.B14 | tunicamycin | inhibition of N-glycosylation by tunicamycin reduces the enzymatic activity of extracellular NEP2 to about 50% and the molecular size of intracellular NEP2 | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.11 | Mus musculus | - |
- |
- |
3.4.24.B14 | Mus musculus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.B14 | glycoprotein | - |
Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B14 | additional information | does not cleave dansyl-D-Ala-Gly-p-nitro-Phe-Gly | Mus musculus | ? | - |
? | |
3.4.24.B14 | succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | succinyl-Ala-Ala + Phe-7-amido-4-methylcoumarin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.11 | NEP2 | - |
Mus musculus |
3.4.24.11 | NL-1 | - |
Mus musculus |
3.4.24.11 | SEP | - |
Mus musculus |
3.4.24.B14 | NEP2 | - |
Mus musculus |
3.4.24.B14 | neprilysin 2 | - |
Mus musculus |
3.4.24.B14 | NL-1 | - |
Mus musculus |
3.4.24.B14 | SEP | - |
Mus musculus |