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Literature summary extracted from

  • Oh-Hashi, K.; Ohkubo, K.; Shizu, K.; Fukuda, H.; Hirata, Y.; Kiuchi, K.
    Biosynthesis, processing, trafficking, and enzymatic activity of mouse neprilysin 2 (2008), Mol. Cell. Biochem., 313, 103-111.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B14 expressed in HEK293 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 thiorphan
-
Mus musculus
3.4.24.B14 calcium ionophore A23187 0.001 mM Mus musculus
3.4.24.B14 forskolin 0.01 mM Mus musculus
3.4.24.B14 additional information disruption of the Golgi apparatus with brefeldin A markedly reduces extracellular NEP2 activity in parallel with intracellular NEP2 protein level in HEK293 cells; nocodazole and cytochalasin B barely affect NEP2 activity Mus musculus
3.4.24.B14 thapsigargin 0.0001 mM Mus musculus
3.4.24.B14 tunicamycin inhibition of N-glycosylation by tunicamycin reduces the enzymatic activity of extracellular NEP2 to about 50% and the molecular size of intracellular NEP2 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Mus musculus
-
-
-
3.4.24.B14 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B14 glycoprotein
-
Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B14 additional information does not cleave dansyl-D-Ala-Gly-p-nitro-Phe-Gly Mus musculus ?
-
?
3.4.24.B14 succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
Mus musculus succinyl-Ala-Ala + Phe-7-amido-4-methylcoumarin
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.11 NEP2
-
Mus musculus
3.4.24.11 NL-1
-
Mus musculus
3.4.24.11 SEP
-
Mus musculus
3.4.24.B14 NEP2
-
Mus musculus
3.4.24.B14 neprilysin 2
-
Mus musculus
3.4.24.B14 NL-1
-
Mus musculus
3.4.24.B14 SEP
-
Mus musculus