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Literature summary extracted from

  • Itoh, Y.; Ito, N.; Nagase, H.; Evans, R.D.; Bird, S.A.; Seiki, M.
    Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP (2006), Mol. Biol. Cell, 17, 5390-5399.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.80 expressed in Escherichia coli BL21(DE3)pLysS cells and COS-7 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.80 MT1F-DELTACat catalytic domain-deletion mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.80 GM6001 0.1 mM Homo sapiens
3.4.24.80 hemopexin soluble hemopexin domain inhibits collagenolysis by preventing dimerization Homo sapiens
3.4.24.80 additional information not inhibited by TIMP-1 Homo sapiens
3.4.24.80 TIMP-2 0.0005 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.80 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.80 Type I collagen + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.80 homodimer homodimerization of MT1-MMP through its hemopexin domain is essential for cleaving type I collagen fibers at the cell surface Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 membrane-type 1 matrix metalloproteinase
-
 Homo sapiens
3.4.24.80 MMP-14
-
 Homo sapiens
3.4.24.80 MT1-MMP
-
 Homo sapiens