Literature summary extracted from

Gillespie, J.R.; Yokoyama, K.; Lu, K.; Eastman, R.T.; Bollinger, J.G.; Van Voorhis, W.C.; Gelb, M.H.; Buckner, F.S.
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins (2007), Mol. Biochem. Parasitol., 153, 115-124.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.99.B1	membranes from Sf9 cells expressing the RCE1 ortholog of Leishmania major show proteolytic activity against farnesylated RAS-CVIM	Leishmania major
3.4.99.B1	membranes from Sf9 cells expressing the RCE1 ortholog of Trypanosoma brucei show proteolytic activity against farnesylated RAS-CVIM	Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.99.B1	additional information	Trypanosoma brucei	the Trypanosoma brucei RCE1 ortholog appears to be the dominant prenyl-CaaX protease	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.99.B1	Leishmania major	-	-	-
3.4.99.B1	Trypanosoma brucei	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.99.B1	additional information	the Trypanosoma brucei RCE1 ortholog appears to be the dominant prenyl-CaaX protease	Trypanosoma brucei	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.99.B1	Ras converting enzyme 1	-	Trypanosoma brucei
3.4.99.B1	Ras converting enzyme 1	-	Leishmania major
3.4.99.B1	RCE1	-	Trypanosoma brucei
3.4.99.B1	RCE1	-	Leishmania major

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Release 2023.1 (January 2023)