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Literature summary extracted from

  • Carman, G.M.; Wu, W.I.
    Lipid phosphate phosphatases from Saccharomyces cerevisiae (2007), Methods Enzymol., 434, 305-315.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 overexpression in Spodoptera frugiperda Sf9 cells using the baculovirus expression system, and in Saccharomyces cerevisiae using multicopy plasmids Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 diacylglycerol diphosphate
-
 Saccharomyces cerevisiae
3.1.3.4 NEM
-
 Saccharomyces cerevisiae
3.1.3.4 phosphatidic acid substrate inhibition Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 membrane lipid phosphate phosphatase enzymes possess a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane Saccharomyces cerevisiae 16020
-
3.1.3.4 microsome
-
 Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O Saccharomyces cerevisiae lipid phosphate phosphatase enzymes may play a role in signal transduction by terminating signaling events of lipid phosphates 1,2-diacylglycerol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Saccharomyces cerevisiae
-
 gene llp1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 additional information the enzyme also shows diacylglycerol lipase activity, EC 3.1.1.34, overview Saccharomyces cerevisiae ?
-
 ?
3.1.3.4 phosphatidic acid + H2O lipid phosphate phosphatase enzymes may play a role in signal transduction by terminating signaling events of lipid phosphates Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate
-
 ?
3.1.3.4 phosphatidic acid + H2O the conserved arginine residue in domain 1 and the conserved histidine residues in domains 2 and 3 are essential for catalytic activity Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.4 More lipid phosphate phosphatase enzymes possess a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane, the conserved arginine residue in domain 1 and the conserved histidine residues in domains 2 and 3 are essential for catalytic activity Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipid phosphate phosphatase
-
 Saccharomyces cerevisiae
3.1.3.4 LLP1
-
 Saccharomyces cerevisiae
3.1.3.4 More cf. EC 3.1.1.34 Saccharomyces cerevisiae
3.1.3.4 PA phosphatase
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.4 30
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 6.5
-
 assay at Saccharomyces cerevisiae