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Literature summary extracted from

  • McDermott, M.I.; Sigal, Y.J.; Crump, J.S.; Morris, A.J.
    Enzymatic analysis of lipid phosphate phosphatases (2006), Methods, 39, 169-179.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.4 analysis radiolabeled and fluorescent lipid substrates for the detection, quantitation and analysis of the enzymatic activities of the LPPs measured using intact or broken cell preparations as the source of enzyme Mus musculus
3.1.3.4 analysis radiolabeled and fluorescent lipid substrates for the detection, quantitation and analysis of the enzymatic activities of the LPPs measured using intact or broken cell preparations as the source of enzyme Homo sapiens
3.1.3.4 analysis radiolabeled and fluorescent lipid substrates for the detection, quantitation and analysis of the enzymatic activities of the LPPs measured using intact or broken cell preparations as the source of enzyme Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 transient and stable overexpression in HEK-293 cells, baculovirus vectors for recombinant expression of LPPs in cultured Sf9 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 additional information insensitive to inhibition by the alkylating agent N-ethyl maleimide Homo sapiens
3.1.3.4 additional information insensitive to inhibition by the alkylating agent N-ethyl maleimide Rattus norvegicus
3.1.3.4 propranolol moderately effective inhibitor of LPP activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 membrane
-
 Mus musculus 16020
-
3.1.3.4 membrane
-
 Homo sapiens 16020
-
3.1.3.4 membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 additional information independent of divalent metal ions Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-
3.1.3.4 Mus musculus
-
-
-
3.1.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 HEK-293 cell
-
 Homo sapiens
-
3.1.3.4 additional information Swiss 3T3 cell Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 ceramide 1-phosphate + H2O
-
 Homo sapiens ceramide + phosphate
-
 ?
3.1.3.4 ceramide 1-phosphate + H2O
-
 Rattus norvegicus ceramide + phosphate
-
 ?
3.1.3.4 lyso-phosphatidic acid + H2O
-
 Homo sapiens monoacylglycerol + phosphate
-
 ?
3.1.3.4 lyso-phosphatidic acid + H2O
-
 Rattus norvegicus monoacylglycerol + phosphate
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Homo sapiens diacylglycerol + phosphate
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Rattus norvegicus diacylglycerol + phosphate
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O
-
 Homo sapiens sphingosine + phosphate
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O
-
 Rattus norvegicus sphingosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 LPP1
-
 Homo sapiens
3.1.3.4 LPP2
-
 Homo sapiens
3.1.3.4 LPP3
-
 Mus musculus
3.1.3.4 LPP3
-
 Homo sapiens
3.1.3.4 LPP3
-
 Rattus norvegicus