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Literature summary extracted from

  • Finnegan, C.M.; Rawat, S.S.; Cho, E.H.; Guiffre, D.L.; Lockett, S.; Merrill, A.H.; Blumenthal, R.
    Sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion (2007), J. Virol., 81, 5294-5304.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 plasma membrane
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 Bacillus cereus 5886
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Bacillus cereus sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion at a step in the fusion process after CD4 engagement, but sphingomyelinase treatment of cells does not influence gp120 binding, HIV-1 attachment, or fluid-phase and receptor-mediated endocytosis, and furthermore, sphingomyelinase treatment does not affect the membrane disposition of the HIV receptor proteins CD4, CXCR4, and CCR5, Smase treatment does not influence Triton X-100 extraction of HIV-1 receptor proteins, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Bacillus cereus Smase cleaves sphingomyelin at the outer leaflet of the plasma membrane, generating phosphocholine and ceramide N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bacillus cereus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 HeLa cell
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 Bacillus cereus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion at a step in the fusion process after CD4 engagement, but sphingomyelinase treatment of cells does not influence gp120 binding, HIV-1 attachment, or fluid-phase and receptor-mediated endocytosis, and furthermore, sphingomyelinase treatment does not affect the membrane disposition of the HIV receptor proteins CD4, CXCR4, and CCR5, Smase treatment does not influence Triton X-100 extraction of HIV-1 receptor proteins, overview Bacillus cereus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bacillus cereus N-acylsphingosine + choline phosphate
-
 ?
3.1.4.12 sphingomyelin + H2O Smase cleaves sphingomyelin at the outer leaflet of the plasma membrane, generating phosphocholine and ceramide Bacillus cereus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 SMase
-
 Bacillus cereus
3.1.4.12 sphingomyelinase
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 Bacillus cereus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 in vivo assay at Bacillus cereus