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Literature summary extracted from
- Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17 (2007), J. Thromb. Haemost., 5, 395-402.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | phorbol-12-myristate 13-acetate | - |
Homo sapiens |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.86 | additional information | endothelial protein C receptor shedding is not influenced by DMSO, TIMP-1 or TIMP-2 | Homo sapiens | |
| 3.4.24.86 | TNF-alpha proteinase inhibitor | 0.00005 mM | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.86 | HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.86 | endothelial protein C receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.86 | proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.86 | ADAM17 | - |
Homo sapiens |
| 3.4.24.86 | TACE | - |
Homo sapiens |
| 3.4.24.86 | tumor necrosis factor-alpha converting enzyme | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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