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Literature summary extracted from
- PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6) (2007), J. Pharmacol. Exp. Ther., 322, 600-609.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.53 | cilomilast | - |
Homo sapiens |  |
| 3.1.4.53 | cilomilast | - |
Mus musculus | |
| 3.1.4.53 | rolipram | - |
Homo sapiens | |
| 3.1.4.53 | rolipram | - |
Mus musculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.53 | 0.0058 | - |
adenosine 3',5'-cyclic phosphate | - |
Mus musculus | |
| 3.1.4.53 | 0.0058 | - |
cAMP | 30°C | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.53 | cytosol | uneven and predominant localization | Homo sapiens | 5829 | - |
| 3.1.4.53 | cytosol | PDE4B5 is distributed predominantly and unevenly within the cytosol | Mus musculus | 5829 | - |
| 3.1.4.53 | plasma membrane | small part of enzyme is associated with the plasma membrane | Homo sapiens | 5886 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.53 | 58000 | - |
- |
Mus musculus |
| 3.1.4.53 | 58000 | - |
x * 58000, SDS-PAGE of isoform PDE4B5 | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.53 | Homo sapiens | Q07343 | isoform PDE4B5, variant of PDE4B with a different 5'-terminus | - |
| 3.1.4.53 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.53 | brain | isoform PDE4B5 is brain-specific | Homo sapiens | - |
| 3.1.4.53 | brain | PDE4B5 is brain-specific | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.53 | 3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
| 3.1.4.53 | adenosine 3',5'-cyclic phosphate + H2O | - |
Mus musculus | adenosine 5'-phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.4.53 | ? | x * 58000, SDS-PAGE of isoform PDE4B5 | Homo sapiens |
| 3.1.4.53 | More | isoform PDE4B5 is able to bind the scaffold protein DISC1 | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.53 | PDE4B5 | PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 | Mus musculus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.53 | 0.000097 | - |
cilomilast | - |
Mus musculus | |
| 3.1.4.53 | 0.000114 | - |
cilomilast | 30°C | Homo sapiens | |
| 3.1.4.53 | 0.000324 | - |
rolipram | - |
Mus musculus | |
| 3.1.4.53 | 0.00038 | - |
rolipram | 30°C | Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.53 | 0.000114 | - |
- |
Mus musculus | cilomilast | |
| 3.1.4.53 | 0.00038 | - |
- |
Mus musculus | rolipram | |
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Release 2023.1 (January 2023)
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